4-Cinnolinethiol, with the CAS number 875-67-2, is an organic compound characterized by the presence of a cinnoline ring, which is a bicyclic structure composed of two fused nitrogen-containing rings. This compound features a thiol (-SH) functional group, which imparts distinct chemical properties, including the ability to form hydrogen bonds and participate in redox reactions. 4-Cinnolinethiol is typically a yellow to brown solid at room temperature and is soluble in polar solvents due to its thiol group. It exhibits moderate stability under standard conditions but can be sensitive to oxidation. The compound is of interest in various fields, including medicinal chemistry and materials science, due to its potential biological activities and applications in synthesizing other chemical entities. Its reactivity can be influenced by the presence of the thiol group, making it a useful precursor in organic synthesis and a candidate for further functionalization. Safety precautions should be observed when handling this compound, as thiols can have strong odors and may be toxic in certain concentrations.

4-Cinnolinethiol

875-67-2: 4-Cinnolinethiol, with the CAS number 875-67-2, is an organic compound characterized by the presence of a cinnoline ring, which is a bicyclic structure composed of two fused nitrogen-containing rings. This compound features a thiol (-SH) functional group, which imparts distinct chemical properties, including the ability to form hydrogen bonds and participate in redox reactions. 4-Cinnolinethiol is typically a yellow to brown solid at room temperature and is soluble in polar solvents due to its thiol group. It exhibits moderate stability under standard conditions but can be sensitive to oxidation. The compound is of interest in various fields, including medicinal chemistry and materials science, due to its potential biological activities and applications in synthesizing other chemical entities. Its reactivity can be influenced by the presence of the thiol group, making it a useful precursor in organic synthesis and a candidate for further functionalization. Safety precautions should be observed when handling this compound, as thiols can have strong odors and may be toxic in certain concentrations.

<p>Cinnoline-4-thiol is an inhibitor of the protein PD-L1, which is a targetable tumor antigen. It blocks the interaction between PD-L1 and its receptor CTLA-4, thereby inhibiting the activation of T cells and reducing their proliferation. This molecule has been shown to have anti-tumor activity in vitro and in vivo. Cinnoline-4-thiol has been shown to inhibit tumor growth by suppressing cancer cell proliferation. It also induces apoptosis, which leads to cancer cell death by activating caspases. Cinnoline-4-thiol has been shown to be active against many different types of cancers, including breast cancer, colorectal cancer, non-small cell lung cancer, ovarian carcinoma, pancreatic cancer and prostate cancer.</p>

CAS 875-67-2

4-Cinnolinethiol

Cinnoline-4-thiol

Ref: 3D-AAA87567