CAS 875320-29-9

Quisinostat

Description:

Quisinostat is a chemical compound classified as a histone deacetylase (HDAC) inhibitor, which plays a significant role in the regulation of gene expression and is being investigated for its potential therapeutic applications, particularly in cancer treatment. Its mechanism of action involves the inhibition of HDAC enzymes, leading to an increase in the acetylation of histones and non-histone proteins, which can result in altered gene expression patterns that may induce cell cycle arrest, differentiation, and apoptosis in cancer cells. Quisinostat is characterized by its specific structural features that contribute to its biological activity, including a unique functional group arrangement that enhances its binding affinity to HDAC targets. The compound has been studied in various preclinical and clinical settings, demonstrating potential efficacy against certain malignancies. However, like many investigational drugs, its safety profile, optimal dosing, and long-term effects are subjects of ongoing research. Overall, Quisinostat represents a promising avenue in the field of epigenetic therapy.

Formula: C₂₁H₂₆N₆O₂

InChI: InChI=1S/C21H26N6O2/c1-26-14-17(18-4-2-3-5-19(18)26)11-22-10-15-6-8-27(9-7-15)21-23-12-16(13-24-21)20(28)25-29/h2-5,12-15,22,29H,6-11H2,1H3,(H,25,28)

InChI key: InChIKey=PAWIYAYFNXQGAP-UHFFFAOYSA-N

SMILES: C(NCC1CCN(CC1)C=2N=CC(C(NO)=O)=CN2)C=3C=4C(N(C)C3)=CC=CC4

Synonyms:

• 5-Pyrimidinecarboxamide, N-hydroxy-2-[4-[[[(1-methyl-1H-indol-3-yl)methyl]amino]methyl]-1-piperidinyl]-
• Jnj 26481585
• N-Hydroxy-2-[4-[[[(1-methyl-1H-indol-3-yl)methyl]amino]methyl]-1-piperidinyl]-5-pyrimidinecarboxamide
• N1-(2-(1h-indol-3-yl)ethyl)-n4-(pyridin-4-yl)benzene-1,4-diamine
• Quisinostat

N1-(2-(1H-Indol-3-yl)ethyl)-n4-(pyridin-4-yl)benzene-1,4-diamine

CAS: 875320-29-9

Formula: C₂₁H₂₆N₆O₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 394.4701

Ref: IN-DA008C3Z

Quisinostat

CAS: 875320-29-9

Ref: 7W-GW1499

Quisinostat

CAS: 875320-29-9

Quisinostat (JNJ-26481585), a second-gen HDAC inhibitor, is most potent for HDAC1 (IC50 0.11 nM) and selectively affects HDACs 2, 4, 10, and 11.

Formula: C₂₁H₂₆N₆O₂

Purity: 96.01% - ≥98%

Color and Shape: Solid

Molecular weight: 394.47

Ref: TM-T6055

JNJ-26481585

Controlled Product

CAS: 875320-29-9

Formula: C₂₁H₂₆N₆O₂

Color and Shape: Neat

Molecular weight: 394.47

Ref: TR-J211333

JNJ-26481585-d3

Controlled Product

CAS: 875320-29-9

Formula: C₂₁D₃H₂₃N₆O₂

Color and Shape: Neat

Molecular weight: 397.489

Ref: TR-J211334

JNJ-26481585-d3

Controlled Product

CAS: 875320-29-9

JNJ-26481585-d3 is a potent and selective histone deacetylase inhibitor that has been shown to inhibit the growth of tumor cells by inducing apoptosis. JNJ-26481585-d3 selectively inhibits the activity of histone deacetylases, which are enzymes that remove acetyl groups from lysine residues in histones. The inhibition of these enzymes leads to transcriptional silencing of genes, which is an important step in cancer development. The minimal toxicity of this drug makes it suitable for long-term treatment with low doses.

Formula: C₂₁H₂₃D₃N₆O₂

Purity: Min. 95%

Molecular weight: 397.49 g/mol

Ref: 3D-AKB32029