CAS 875320-31-3

5-Pyrimidinecarboxamide, N-hydroxy-2-[4-[[[(1-methyl-1H-indol-3-yl)methyl]amino]methyl]-1-piperidinyl]-, hydrochloride (1:2)

Description:

5-Pyrimidinecarboxamide, N-hydroxy-2-[4-[[[(1-methyl-1H-indol-3-yl)methyl]amino]methyl]-1-piperidinyl]-, hydrochloride (1:2) is a chemical compound characterized by its complex structure, which includes a pyrimidine ring, an indole moiety, and a piperidine group. This compound is typically classified as a pharmaceutical agent, potentially exhibiting biological activity due to its diverse functional groups. The presence of the N-hydroxy group suggests potential reactivity and interactions with biological targets, making it of interest in medicinal chemistry. The hydrochloride salt form indicates enhanced solubility in aqueous environments, which is advantageous for drug formulation and delivery. Its molecular structure may contribute to specific pharmacological properties, including enzyme inhibition or receptor modulation. As with many compounds in drug development, its safety, efficacy, and mechanism of action would require thorough investigation through preclinical and clinical studies. Overall, this compound exemplifies the complexity often found in modern pharmaceuticals, combining multiple pharmacophores to achieve desired therapeutic effects.

Formula: C₂₁H₂₈Cl₂N₆O₂

InChI: InChI=1S/C21H26N6O2.2ClH/c1-26-14-17(18-4-2-3-5-19(18)26)11-22-10-15-6-8-27(9-7-15)21-23-12-16(13-24-21)20(28)25-29;;/h2-5,12-15,22,29H,6-11H2,1H3,(H,25,28);2*1H

InChI key: InChIKey=NRUIZESXVMJDKR-UHFFFAOYSA-N

SMILES: C(NCC1CCN(CC1)C=2N=CC(C(NO)=O)=CN2)C=3C=4C(N(C)C3)=CC=CC4.Cl

Synonyms:

• 5-Pyrimidinecarboxamide, N-hydroxy-2-[4-[[[(1-methyl-1H-indol-3-yl)methyl]amino]methyl]-1-piperidinyl]-, hydrochloride (1:2)
• 5-Pyrimidinecarboxamide, N-hydroxy-2-[4-[[[(1-methyl-1H-indol-3-yl)methyl]amino]methyl]-1-piperidinyl]-, dihydrochloride
• JNJ26854165(Quisinostat) 2HCl
• JNJ 26481585 dihydrochloride - Quisinostat dihydrochloride
• JNJ-26481585 2HCl
• JNJ 26481585 dihydrochloride
• Quisinostat 2HCl, 98%, a new type HDAC inhibitor
• JNJ26854165 2HCL
• Quisinostat dihydrochloride
• Quisinostat 2HCl

JNJ26854165(Quisinostat) 2HCl

CAS: 875320-31-3

Formula: C₂₁H₂₈Cl₂N₆O₂

Purity: 97%

Color and Shape: Solid

Molecular weight: 467.3920

Ref: IN-DA00H1M1

Quisinostat dihydrochloride

CAS: 875320-31-3

Quisinostat dihydrochloride (JNJ26854165(Quisinostat) 2HCl) 是一种有口服活性，高效的 pan-HDAC 抑制剂，具有广泛的抗肿瘤活性。它对 HDAC1、HDAC2、HDAC4、HDAC10和HDAC11 的IC50值分别为 0.11 nM、0.33 nM、0.64 nM、0.46 nM 和 0.37 nM。

Formula: C₂₁H₂₈Cl₂N₆O₂

Purity: 97.13%

Color and Shape: Solid

Molecular weight: 467.39

Ref: TM-T6865