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CAS 875446-37-0

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Anacetrapib

Description:
Anacetrapib is a small molecule that belongs to the class of compounds known as CETP (cholesteryl ester transfer protein) inhibitors. It is primarily investigated for its potential in treating dyslipidemia and cardiovascular diseases by modulating lipid profiles, particularly by increasing high-density lipoprotein (HDL) cholesterol levels and reducing low-density lipoprotein (LDL) cholesterol levels. Anacetrapib is characterized by its ability to inhibit the CETP enzyme, which plays a crucial role in the transfer of cholesterol esters and triglycerides between lipoproteins. The compound has a relatively high affinity for CETP, which contributes to its efficacy. In clinical studies, Anacetrapib has demonstrated a favorable safety profile, although its long-term effects and benefits in reducing cardiovascular events are still under investigation. Its chemical structure includes a complex arrangement of functional groups that contribute to its biological activity. Overall, Anacetrapib represents a promising therapeutic approach in lipid management, although further research is needed to fully understand its clinical implications.
Formula:C30H25F10NO3
InChI:InChI=1S/C30H25F10NO3/c1-14(2)22-11-23(25(43-4)12-24(22)31)21-6-5-18(28(32,33)34)9-17(21)13-41-15(3)26(44-27(41)42)16-7-19(29(35,36)37)10-20(8-16)30(38,39)40/h5-12,14-15,26H,13H2,1-4H3/t15-,26-/m0/s1
InChI key:InChIKey=MZZLGJHLQGUVPN-HAWMADMCSA-N
SMILES:C(C1=C(C=CC(C(F)(F)F)=C1)C2=C(OC)C=C(F)C(C(C)C)=C2)N3[C@@H](C)[C@H](OC3=O)C4=CC(C(F)(F)F)=CC(C(F)(F)F)=C4
Synonyms:
  • (4S,5R)-5-[3,5-Bis(trifluoromethyl)phenyl]-3-[[4′-fluoro-2′-methoxy-5′-(1-methylethyl)-4-(trifluoromethyl)[1,1′-biphenyl]-2-yl]methyl]-4-methyl-2-oxazolidinone
  • (4S,5R)-5-[3,5-Bis(trifluoromethyl)phenyl]-3-[[4′-fluoro-5′-isopropyl-2′-methoxy-4-(trifluoromethyl)biphenyl-2-yl]methyl]-4-methyl-1,3-oxazolidin-2-one
  • 2-Oxazolidinone, 5-[3,5-bis(trifluoromethyl)phenyl]-3-[[4′-fluoro-2′-methoxy-5′-(1-methylethyl)-4-(trifluoromethyl)[1,1′-biphenyl]-2-yl]methyl]-4-methyl-, (4S,5R)-
  • Anacetrapib
  • Anacetrapib (With 3 Ints.)
  • Anacetrpib
  • Mk 0859
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