CAS 87614-40-2

diazaquinomycin A

Description:

Diazaquinomycin A is a naturally occurring compound classified as an antibiotic, specifically belonging to the class of quinomycin antibiotics. It is characterized by its complex polycyclic structure, which includes two nitrogen atoms in its molecular framework, contributing to its name "diaza." This compound exhibits notable biological activity, particularly against certain bacterial strains, making it of interest in medicinal chemistry and microbiology. Diazaquinomycin A functions by interfering with nucleic acid synthesis, which is a common mechanism among antibiotics. Its unique structure allows it to bind to DNA, inhibiting the activity of essential enzymes involved in replication and transcription. The compound's potential therapeutic applications are being explored, particularly in the context of antibiotic resistance. Additionally, its synthesis and modification are subjects of research aimed at enhancing its efficacy and reducing toxicity. Overall, diazaquinomycin A represents a significant area of study within the field of natural products and antibiotic development.

Formula: C₂₀H₂₂N₂O₄

InChI: InChI=1/C20H22N2O4/c1-5-7-11-9(3)19(25)21-15-13(11)17(23)14-12(8-6-2)10(4)20(26)22-16(14)18(15)24/h5-8H2,1-4H3,(H,21,25)(H,22,26)

Synonyms:

• Pyrido[3,2-g]quinoline-2,5,8,10(1H,9H)-tetrone, 3,7-dimethyl-4,6-dipropyl-
• Diazaquinomycin
• diazaquinomycin A

Diazaquinomycin A

CAS: 87614-40-2

Diazaquinomycin A (DAQA) is a diazaquinomycin antibiotic that acts as an inhibitor of thymidylate synthase. DAQA induces DNA damage, cell cycle arrest, and apoptosis through cleavage of PARP.

Formula: C₂₀H₂₂N₂O₄

Color and Shape: Solid

Molecular weight: 354.4

Ref: TM-TN10150