CAS 876310-60-0

N2-(Tricyclo[3.3.1.13,7]dec-1-ylcarbonyl)-L-arginyl-L-phenylalaninamide

Description:

N2-(Tricyclo[3.3.1.13,7]dec-1-ylcarbonyl)-L-arginyl-L-phenylalaninamide is a synthetic compound characterized by its complex structure, which includes a tricyclic framework and amino acid derivatives. The presence of the tricyclo[3.3.1.13,7]decane moiety contributes to its unique three-dimensional conformation, potentially influencing its biological activity and interactions. The compound features an arginine residue, known for its role in various physiological processes, including protein synthesis and nitric oxide production, and a phenylalanine derivative, which may enhance hydrophobic interactions. The amide functional group indicates potential for hydrogen bonding, affecting solubility and reactivity. This compound may be of interest in medicinal chemistry and pharmacology due to its structural complexity and the presence of amino acid components, which can mimic natural peptides or proteins. Its specific applications and biological activities would depend on further studies, including pharmacokinetics and mechanism of action. As with many synthetic compounds, safety and handling precautions should be observed, given the potential for biological activity.

Formula: C₂₆H₃₈N₆O₃

InChI: InChI=1S/C26H38N6O3/c27-22(33)21(12-16-5-2-1-3-6-16)31-23(34)20(7-4-8-30-25(28)29)32-24(35)26-13-17-9-18(14-26)11-19(10-17)15-26/h1-3,5-6,17-21H,4,7-15H2,(H2,27,33)(H,31,34)(H,32,35)(H4,28,29,30)/t17?,18?,19?,20-,21-,26?/m0/s1

InChI key: InChIKey=UMKHUSRDQFQHAK-RNJMTYCLSA-N

SMILES: C(N[C@H](C(N[C@@H](CC1=CC=CC=C1)C(N)=O)=O)CCCNC(=N)N)(=O)C23CC4CC(C2)CC(C3)C4

Synonyms:

• 2-Adamantanecarbonyl-Arg-Phe-Nh2 Trifluoroacetate
• <span class="text-smallcaps">L</smallcap>-Phenylalaninamide, N²-(tricyclo[3.3.1.1^3,7]dec-1-ylcarbonyl)-<smallcap>L</span>-arginyl-
• N²-(Tricyclo[3.3.1.1^3,7]dec-1-ylcarbonyl)-<span class="text-smallcaps">L</smallcap>-arginyl-<smallcap>L</span>-phenylalaninamide
• Rf 9
• 16: PN: WO2011144714 SEQID: 16 claimed sequence
• N2-(Tricyclo[3.3.1.13,7]dec-1-ylcarbonyl)-L-arginyl-L-phenylalaninamide
• L-Phenylalaninamide, N2-(tricyclo[3.3.1.13,7]dec-1-ylcarbonyl)-L-arginyl-

2-ADAMANTANECARBONYL-ARG-PHE-NH2 TRIFLUOROACETATE

CAS: 876310-60-0

Formula: C₂₆H₃₈N₆O₃

Purity: 95%

Color and Shape: Solid

Molecular weight: 482.6183

Ref: IN-DA00GV3S

RF9

CAS: 876310-60-0

RF9 is an effective and selective antagonist of the Neuropeptide FF receptor (Kis: 58±5 and 75±9 nM for hNPFF1R and hNPFF2R, respectively).

Formula: C₂₆H₃₈N₆O₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 482.62

Ref: TM-T16738

RF9 trifluoroacetate salt

CAS: 876310-60-0

RF9 is a dipeptide that is structurally similar to the endogenous neuropeptides kisspeptin and arginine-vasopressin. RF9 binds to the GPR54 receptor, which is a G protein-coupled receptor that regulates secretion of luteinizing hormone in the anterior pituitary gland, as well as sexual desire and function. RF9 has been shown to be an antagonist of the GPR54 receptor and has been shown to inhibit the secretion of luteinizing hormone in primates.

Formula: C₂₆H₃₈N₆O₃

Purity: Min. 95%

Molecular weight: 482.62 g/mol

Ref: 3D-FR108335

RF9

CAS: 876310-60-0

Potent and selective neuropeptide FF (NPFF) receptor antagonist. RF9 (1-Adamantanecarbonyl-Arg-Phe-NH₂) blocked the delayed and long-lasting paradoxical opioid-induced hyperalgesia and prevented the development of associated tolerance. RF9 could also efficiently block the increase in blood pressure and heart rate evoked by NPFF.

Formula: C₂₆H₃₈N₆O₃

Purity: 98.7%

Color and Shape: White Powder

Molecular weight: 482.63

Ref: 01-4061350