AR antagonist 6, identified by its CAS number 876760-08-6, is a chemical compound that functions as an antagonist for androgen receptors (AR). This class of compounds is typically characterized by their ability to inhibit the action of androgens, which are hormones that play a crucial role in the development and maintenance of male characteristics. AR antagonists are often explored for their potential therapeutic applications in conditions such as prostate cancer, where blocking androgen activity can slow tumor growth. The structure of AR antagonist 6 likely includes specific functional groups that confer its binding affinity to the androgen receptor, thereby preventing the receptor from activating gene expression associated with androgen signaling. Additionally, compounds in this category may exhibit varying degrees of selectivity and potency, influencing their effectiveness and side effect profiles. As with many pharmacological agents, the safety, efficacy, and pharmacokinetics of AR antagonist 6 would be evaluated through preclinical and clinical studies to determine its suitability for therapeutic use.

AR antagonist 6

876760-08-6: AR antagonist 6, identified by its CAS number 876760-08-6, is a chemical compound that functions as an antagonist for androgen receptors (AR). This class of compounds is typically characterized by their ability to inhibit the action of androgens, which are hormones that play a crucial role in the development and maintenance of male characteristics. AR antagonists are often explored for their potential therapeutic applications in conditions such as prostate cancer, where blocking androgen activity can slow tumor growth. The structure of AR antagonist 6 likely includes specific functional groups that confer its binding affinity to the androgen receptor, thereby preventing the receptor from activating gene expression associated with androgen signaling. Additionally, compounds in this category may exhibit varying degrees of selectivity and potency, influencing their effectiveness and side effect profiles. As with many pharmacological agents, the safety, efficacy, and pharmacokinetics of AR antagonist 6 would be evaluated through preclinical and clinical studies to determine its suitability for therapeutic use.

<p>AR antagonist 6 (compound 6i), a diphenyl ether androgen receptor (AR) antagonist, binds to the AR with an affinity of 120 nM. It demonstrates low toxicity and effective in vitro activity in the golden Syrian hamster ear model. [19] [1]</p>

CAS 876760-08-6

AR antagonist 6

AR antagonist 6

Ref: TM-T85718