CAS 87679-37-6

Trandolapril

Description:

Trandolapril is an angiotensin-converting enzyme (ACE) inhibitor primarily used in the treatment of hypertension and heart failure. It is a white to off-white crystalline powder that is soluble in water and organic solvents. The chemical formula of Trandolapril is C24H34N2O5, and it has a molecular weight of approximately 426.54 g/mol. The substance works by inhibiting the ACE enzyme, which plays a crucial role in the renin-angiotensin-aldosterone system, leading to vasodilation and reduced blood pressure. Trandolapril is typically administered orally and is often prescribed in combination with other antihypertensive agents. Its pharmacokinetics include a prodrug nature, as it is converted to its active form, Trandolaprilat, in the body. Common side effects may include dizziness, fatigue, and gastrointestinal disturbances. As with other ACE inhibitors, it is contraindicated in patients with a history of angioedema related to previous ACE inhibitor therapy and during pregnancy due to potential risks to the fetus.

Formula: C₂₄H₃₄N₂O₅

InChI: InChI=1S/C24H34N2O5/c1-3-31-24(30)19(14-13-17-9-5-4-6-10-17)25-16(2)22(27)26-20-12-8-7-11-18(20)15-21(26)23(28)29/h4-6,9-10,16,18-21,25H,3,7-8,11-15H2,1-2H3,(H,28,29)/t16-,18+,19-,20-,21-/m0/s1

InChI key: InChIKey=VXFJYXUZANRPDJ-WTNASJBWSA-N

SMILES: C([C@@H](N[C@@H](CCC1=CC=CC=C1)C(OCC)=O)C)(=O)N2[C@@]3([C@@](C[C@H]2C(O)=O)(CCCC3)[H])[H]

Synonyms:

• 1H-Indole-2-carboxylic acid, 1-[(2S)-2-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]octahydro-, (2S,3aR,7aS)-
• Trandolapril
• (2s,3ar,7as)-1-[(2s)-2-[[(1s)-1-ethoxycarbonyl-3-phenyl-propyl]amino]propanoyl]-2,3,3a,4,5,6,7,7a-octahydroindole-2-carboxylic acid
• 1H-Indole-2-carboxylic acid, 1-[2-[[1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]octahydro-, [2S-[1[R*(R*)],2α,3aα,7aβ]]-
• RU 44570
• (2S,3aR,7aS)-1-[(2S)-2-{[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino}propanoyl]octahydro-1H-indole-2-carboxylic acid (non-preferred name)
• (2S,3aR,7aS)-1-[(2S)-2-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]octahydro-1H-indole-2-carboxylic acid

Trandolapril

CAS: 87679-37-6

Color and Shape: Neat

Ref: 61-FOR0255.00

TRANDOLAPRIL CRS

CAS: 87679-37-6

TRANDOLAPRIL CRS

Formula: C₂₄H₃₄N₂O₅

Color and Shape: Powder

Molecular weight: 430.5372

Ref: 41-Y0000501

Trandolapril

CAS: 87679-37-6

Trandolapril

Formula: C₂₄H₃₄N₂O₅

Purity: 99.6%

Color and Shape: White

Molecular weight: 430.24677

Ref: 47-1089

Trandolapril

CAS: 87679-37-6

Cardiovascular drugs, not elsewhere specified or included

Formula: C₂₄H₃₄N₂O₅

Color and Shape: White Powder

Molecular weight: 430.24677

Ref: 45-1672687

trandolapril

CAS: 87679-37-6

Formula: C₂₄H₃₄N₂O₅

Purity: 98%

Color and Shape: Solid

Molecular weight: 430.5372

Ref: IN-DA004NTA

Trandolapril-d5

CAS: 87679-37-6

Formula: C₂₄H₂₉N₂O₅D₅

Molecular weight: 435.58

Ref: 4Z-T-073

Trandolapril

CAS: 87679-37-6

Formula: C₂₄H₃₄N₂O₅

Molecular weight: 430.55

Ref: 4Z-T-071

Trandolapril

CAS: 87679-37-6

Formula: C₂₄H₃₄N₂O₅

Color and Shape: Neat

Molecular weight: 430.54

Ref: 86-MM0255.00

Trandolapril

CAS: 87679-37-6

Trandolapril is an orally administered angiotensin converting enzyme (ACE) inhibitor that is hydrolysed to the active diacid trandolaprilat.

Formula: C₂₄H₃₄N₂O₅

Purity: 99.70% - 99.83%

Color and Shape: White Powder

Molecular weight: 430.54

Ref: TM-T5329

Trandolapril

CAS: 87679-37-6

Formula: C₂₄H₃₄N₂O₅

Purity: ≥ 98.0%

Color and Shape: White crystalline powder

Molecular weight: 430.54

Ref: 7W-GP8888

Trandolapril

CAS: 87679-37-6

Inhibitor of angiotensin-converting enzyme

Formula: C₂₄H₃₄N₂O₅

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 430.54 g/mol

Ref: 3D-FT28365

trandolapril

CAS: 87679-37-6

Purity: 98%

Molecular weight: 430.5450134

Ref: 10-F862949

Trandolapril

Controlled Product

CAS: 87679-37-6

Applications An antihypertensive. Angiotensin converting enzyme (ACE) inhibitor.
References Brown, N.L., et al.: Eur. J. Pharmacol., 148, 79 (1988), Kober, L., et al.: N. Engl. J. Med., 333, 1670 (1995), Malik, R.A., et al.: Lancet, 352, 1978 (1998)

Formula: C₂₄H₃₄N₂O₅

Color and Shape: Neat

Molecular weight: 430.54

Ref: TR-T713500

Trandolapril-d3

Controlled Product

CAS: 87679-37-6

Applications Trandolapril-d3, is the labeled analogue of Trandolapril (T713500), an antihypertensive. Angiotensin converting enzyme (ACE) inhibitor.
References Brown, N.L., et al.: Eur. J. Pharmacol., 148, 79 (1988), Kober, L., et al.: N. Engl. J. Med., 333, 1670 (1995), Malik, R.A., et al.: Lancet, 352, 1978 (1998)

Formula: C₂₄D₃H₃₁N₂O₅

Color and Shape: Neat

Molecular weight: 433.556

Ref: TR-T713503