CAS 87679-71-8: Trandolaprilat

Description: Trandolaprilat is the active metabolite of the angiotensin-converting enzyme (ACE) inhibitor trandolapril, primarily used in the treatment of hypertension and heart failure. It is characterized by its ability to inhibit the conversion of angiotensin I to angiotensin II, leading to vasodilation and reduced blood pressure. Trandolaprilat is a white to off-white crystalline powder, soluble in water and organic solvents, which facilitates its pharmacological activity. The compound exhibits a long half-life, allowing for once-daily dosing in clinical settings. Its mechanism of action not only helps in lowering blood pressure but also provides renal protective effects, making it beneficial for patients with diabetic nephropathy. Additionally, trandolaprilat may have favorable effects on cardiac remodeling post-myocardial infarction. As with other ACE inhibitors, potential side effects include cough, hyperkalemia, and angioedema, necessitating careful monitoring during treatment. Overall, trandolaprilat is an important therapeutic agent in cardiovascular medicine, contributing to improved patient outcomes in managing hypertension and heart-related conditions.

Formula: C₂₂H₃₀N₂O₅

InChI: InChI=1S/C22H30N2O5/c1-14(23-17(21(26)27)12-11-15-7-3-2-4-8-15)20(25)24-18-10-6-5-9-16(18)13-19(24)22(28)29/h2-4,7-8,14,16-19,23H,5-6,9-13H2,1H3,(H,26,27)(H,28,29)/t14-,16+,17-,18-,19-/m0/s1

InChI key: InChIKey=AHYHTSYNOHNUSH-HXFGRODQSA-N

SMILES: O=C(O)C(NC(C(=O)N1C(C(=O)O)CC2CCCCC12)C)CCC=3C=CC=CC3

Synonyms:

• (2S,3aR,7aS)-1-[(2S)-2-[[(1S)-1-Carboxy-3-phenylpropyl]amino]-1-oxopropyl]octahydro-1H-indole-2-carboxylic acid
• (2S,3aR,7aS)-1-[(2S)-2-{[(1S)-1-Carboxy-3-phenylpropyl]amino}propanoyl]octahydro-1H-indole-2-carboxylic acid (non-preferred name)
• 1H-Indole-2-carboxylic acid, 1-[(2S)-2-[[(1S)-1-carboxy-3-phenylpropyl]amino]-1-oxopropyl]octahydro-, (2S,3aR,7aS)-
• 1H-Indole-2-carboxylic acid, 1-[2-[(1-carboxy-3-phenylpropyl)amino]-1-oxopropyl]octahydro-, [2S-[1[R*(R*)],2α,3aα,7aβ]]-
• Ru 44403
• Trandolaprilate
• Trandolaprilat

Trandolapril impurity E

CAS: 87679-71-8

• Formula: C₂₂H₃₀N₂O₅
• Color and Shape: Light Yellow
• Molecular weight: 402.484

Trandolapril Related Compound E ((2S,3aR,7aS)-1-[N-[(S)-1-Carboxy-3-phenylpropyl]-L-alanyl]hexahydro-2-indolinecarboxylic acid)

CAS: 87679-71-8

Heterocyclic compounds with nitrogen hetero-atom(s) only, aromatic or modified aromatic, nesoi

• Formula: C₂₂H₃₀N₂O₅
• Color and Shape: Powder
• Molecular weight: 402.21547

Trandolaprilat-d5

CAS: 87679-71-8

• Formula: C₂₂H₂₅N₂O₅D₅
• Molecular weight: 407.52

Trandolapril EP Impurity E (Trandolapril USP Related Compound E, Trandolaprilat)

CAS: 87679-71-8

• Formula: C₂₂H₃₀N₂O₅
• Color and Shape: Off-White Solid
• Molecular weight: 402.49

Trandolaprilat

CAS: 87679-71-8

Trandolaprilat is a prodrug of enalaprilat, which is an angiotensin-converting enzyme (ACE) inhibitor. Trandolaprilat binds …

• Formula: C₂₂H₃₂N₂O₆
• Purity: Min. 95%
• Color and Shape: White Powder
• Molecular weight: 420.5 g/mol

Trandolapril EP Impurity E

CAS: 87679-71-8

• Formula: C₂₂H₃₀N₂O₅
• Molecular weight: 402.49

Trandolaprilat

CAS: 87679-71-8

Trandolaprilat is an inhibitor of non-sulfhydryl angiotensin-converting enzyme.

• Formula: C₂₂H₃₀N₂O₅
• Color and Shape: Pale Yellow Solid
• Molecular weight: 402.48