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CAS 87745-28-6

:

(+)-Bryostatin 2

Description:
(+)-Bryostatin 2 is a complex natural product derived from the marine bryozoan Bugula neritina, known for its potential therapeutic applications, particularly in cancer treatment and neurodegenerative diseases. It belongs to a class of compounds called macrolides and is characterized by a unique polycyclic structure that includes a lactone ring. This compound exhibits a range of biological activities, primarily through its role as a modulator of protein kinase C (PKC), influencing various cellular processes such as differentiation, proliferation, and apoptosis. (+)-Bryostatin 2 has been studied for its neuroprotective effects and potential in enhancing memory and cognitive function. Its solubility properties are influenced by its complex structure, making it more soluble in organic solvents than in water. The compound is typically handled with care in laboratory settings due to its biological activity and potential effects on cellular systems. Overall, (+)-Bryostatin 2 represents a significant area of interest in medicinal chemistry and pharmacology, with ongoing research aimed at elucidating its mechanisms of action and therapeutic potential.
Formula:C45H66O16
InChI:InChI=1S/C45H66O16/c1-9-10-11-12-13-14-37(49)59-41-29(21-39(51)56-8)20-32-24-35(27(2)46)58-40(52)23-30(47)22-33-25-36(48)43(5,6)44(53,60-33)26-34-18-28(19-38(50)55-7)17-31(57-34)15-16-42(3,4)45(41,54)61-32/h11-16,19,21,27,30-36,41,46-48,53-54H,9-10,17-18,20,22-26H2,1-8H3/b12-11+,14-13+,16-15+,28-19+,29-21+/t27-,30-,31+,32+,33-,34+,35-,36+,41+,44+,45-/m1/s1
InChI key:InChIKey=LIPGUSBNMQRYNL-IZBIBDMISA-N
SMILES:O(C(/C=C/C=C/CCC)=O)[C@@H]\1[C@@]2(O)O[C@@](C/C1=C\C(OC)=O)(C[C@]([C@@H](C)O)(OC(=O)C[C@H](O)C[C@]3(O[C@@](O)(C[C@]4(O[C@@](\C=C\C2(C)C)(C/C(=C\C(OC)=O)/C4)[H])[H])C(C)(C)[C@@H](O)C3)[H])[H])[H]
Synonyms:
  • 2,4-Octadienoic acid, (1S,3S,5Z,7R,8E,11S,12S,13E,15S,17R,21R,23R,25S)-1,11,21,25-tetrahydroxy-17-[(1R)-1-hydroxyethyl]-5,13-bis(2-methoxy-2-oxoethylidene)-10,10,26,26-tetramethyl-19-oxo-18,27,28,29-tetraoxatetracyclo[21.3.1.13,7.111,15]nonacos-8-en-12-yl ester, (2E,4E)-
  • 18,27,28,29-Tetraoxatetracyclo[21.3.1.13,7.111,15]nonacosane, bryostatin 1 deriv.
  • Bryostatin 1, 7-O-deacetyl-
  • Bryostatin 2
  • 2,4-Octadienoic acid, 1,11,21,25-tetrahydroxy-17-(1-hydroxyethyl)-5,13-bis(2-methoxy-2-oxoethylidene)-10,10,26,26-tetramethyl-19-oxo-18,27,28,29-tetraoxatetracyclo[21.3.1.13,7.111,15]nonacos-8-en-12-yl ester, [1S-[1R*,3R*,5Z,7S*,8E,11R*,12R*(2E,4E),13E,15R*,17S*(S*),21S*,23S*,25R*]]-
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