CAS 87779-49-5
:Bz-Val-Gly-Arg-AMC
Description:
Bz-Val-Gly-Arg-AMC, also known as Benzoyl-Valine-Glycine-Arginine-7-amido-4-methylcoumarin, is a synthetic peptide substrate commonly used in biochemical research, particularly in the study of proteolytic enzymes. This compound features a benzoyl group, which enhances its stability and solubility, and is linked to a sequence of amino acids: valine, glycine, and arginine. The presence of the 7-amido-4-methylcoumarin moiety serves as a fluorescent reporter, allowing for the monitoring of enzymatic activity through fluorescence assays. Bz-Val-Gly-Arg-AMC is particularly useful in the study of proteases, as it can be cleaved by these enzymes, resulting in an increase in fluorescence that can be quantitatively measured. Its characteristics include good solubility in organic solvents and water, stability under physiological conditions, and specificity towards certain proteases, making it a valuable tool in enzymology and drug discovery.
Formula:C30H37N7O6
Synonyms:- Bz-Val-Gly-Arg-Amc Trifluoroacetate Salt
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Found 2 products.
Bz-Val-Gly-Arg-AMC
CAS:Bz-VGR-AMC has been employed as substrate for the tricorn core protease from Thermoplasma acidophilum. Bz-VGR-AMC is used for measuring the trypsin-like activity of the 20S proteasome, in combination with e.g. Suc-LLVY-AMC (for assaying its chymotrypsin-like activity) and Z-LLE-AMC (for determining its PGPH activity).Formula:C30H37N7O6Purity:> 99%Color and Shape:White LyophilisateMolecular weight:591.67Bz-Val-Gly-Arg-AMC trifluoroacetate salt
CAS:<p>Bz-Val-Gly-Arg-AMC is a growth factor that activates the extracellular signal-regulated protein kinase (ERK) pathway. The activation of this pathway results in an increase in cellular proliferation and inhibition of tumor growth. Bz-Val-Gly-Arg-AMC has been shown to activate ERK by interacting with VSMCs, which are cells that act as a structural component of blood vessels and play a role in regulating blood flow. This compound also induces phosphorylation of glycogen synthase kinase 3β and inhibits its activity, leading to increased protein synthesis through glycolysis. Bz-Val-Gly-Arg-AMC can be used as an inhibitor to bortezomib, a proteolytic enzyme that is used to treat cancer.</p>Formula:C30H37N7O6Purity:Min. 95%Molecular weight:591.66 g/mol
