CAS 878592-87-1

Acorafloxacin

Description:

Acorafloxacin is a synthetic fluoroquinolone antibiotic characterized by its broad-spectrum antibacterial activity. It is primarily effective against a variety of Gram-positive and Gram-negative bacteria, making it useful in treating various infections. The compound features a bicyclic core structure typical of fluoroquinolones, which includes a fluorine atom that enhances its antibacterial potency. Acorafloxacin operates by inhibiting bacterial DNA gyrase and topoisomerase IV, enzymes crucial for DNA replication and transcription, thereby disrupting bacterial cell division. Its pharmacokinetic properties include good oral bioavailability and tissue penetration, which contribute to its effectiveness in clinical settings. Additionally, Acorafloxacin has been studied for its potential in treating respiratory and urinary tract infections. As with other antibiotics, the emergence of resistance is a concern, necessitating careful use and monitoring in therapeutic applications. Overall, Acorafloxacin represents a significant advancement in antibiotic therapy, particularly in the context of increasing antibiotic resistance.

Formula: C₂₁H₂₃F₂N₃O₄

InChI: InChI=1S/C21H23F2N3O4/c1-30-20-17-13(19(27)14(21(28)29)10-26(17)12-4-5-12)7-15(22)18(20)25-6-2-3-11(9-25)16(23)8-24/h7,10,12H,2-6,8-9,24H2,1H3,(H,28,29)/b16-11+

InChI key: InChIKey=VMKVDAAFMQKZJS-LFIBNONCSA-N

SMILES: O(C)C1=C2N(C=C(C(O)=O)C(=O)C2=CC(F)=C1N3C/C(=C(\CN)/F)/CCC3)C4CC4

Synonyms:

• 3-Quinolinecarboxylic acid, 7-[(3E)-3-(2-amino-1-fluoroethylidene)-1-piperidinyl]-1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-4-oxo-
• JNJ-Q 2
• 7-[(3E)-3-(2-Amino-1-fluoroethylidene)-1-piperidinyl]-1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid
• Acorafloxacin
• JNJ 32729463AAA

Acorafloxacin

CAS: 878592-87-1

Acorafloxacin is a synthetic fluoroquinolone antibiotic, which is derived from the chemical modification of the quinolone core structure. It acts by inhibiting bacterial DNA gyrase and topoisomerase IV, enzymes crucial for bacterial DNA replication and transcription. The bactericidal action results from preventing the supercoiling and relaxation of the bacterial DNA, ultimately interrupting essential cellular processes.

Formula: C₂₁H₂₃F₂N₃O₄

Purity: Min. 95%

Molecular weight: 419.4 g/mol

Ref: 3D-DKB59287

Avarofloxacin

CAS: 878592-87-1

Avarofloxacin (JNJ-Q2) is a fluoroquinolone for treating bacterial skin infections and pneumonia.

Formula: C₂₁H₂₃F₂N₃O₄

Color and Shape: Solid

Molecular weight: 419.42

Ref: TM-T10420