CAS 879292-24-7

Silodosin β-D-Glucuronide Sodium Salt

Description:

Silodosin β-D-Glucuronide Sodium Salt is a chemical compound that serves as a metabolite of Silodosin, a medication primarily used to treat benign prostatic hyperplasia (BPH). This compound is characterized by its glucuronide conjugate structure, which enhances the solubility and bioavailability of the parent drug. As a sodium salt, it typically exhibits improved stability and solubility in aqueous solutions, making it suitable for pharmaceutical formulations. The compound is expected to have a specific molecular weight and a defined chemical formula, reflecting its unique structure. In terms of pharmacological properties, Silodosin β-D-Glucuronide Sodium Salt may retain some activity related to the α1-adrenergic receptor antagonism, although its efficacy compared to Silodosin itself may vary. Safety and toxicity profiles are generally assessed through preclinical and clinical studies, ensuring that the compound is suitable for therapeutic use. Overall, this metabolite plays a significant role in the pharmacokinetics of Silodosin, influencing its therapeutic effects and potential side effects.

Formula: C₃₁H₄₁F₃N₃NaO₁₀

Synonyms:

• sodium,(2S,3S,4S,5R,6R)-6-[3-[7-carbamoyl-5-[(2R)-2-[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethylamino]propyl]-2,3-dihydroindol-1-yl]propoxy]-3,4,5-trihydroxyoxane-2-carboxylate
• Silodosin Glucuronide (sodium salt)
• Silodosin glucuronide Li Salt
• 3-[7-(AMinocarbonyl)-2,3-dihydro-5-[(2R)-2-[[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl]aMino]propyl]-1H-indol-1-yl]propyl β-D-Glucopyranosiduronic Acid MonosodiuM Salt
• Silodosin β-D-Glucuronide Sodium Salt

Silodosin Glucuronide (sodium salt)

CAS: 879292-24-7

Active metabolite of silodosin, silodosin glucuronide is made by UGT2B7, toxic to rats (LD50: 0.347 mg/kg).

Formula: C₃₁H₃₉F₃N₃NaO₁₀

Color and Shape: Solid

Molecular weight: 693.64

Ref: TM-T36071

Silodosin-D-Glucuronide Ditrifluoroacetate

CAS: 879292-24-7

Formula: C₃₁H₄₀F₃N₃O₁₀·2C₂HF₃O₂

Molecular weight: 671.67 2*114.02

Ref: 4Z-S-2522

Silodosin-d6 β-D-Glucuronide Sodium Salt

Controlled Product

CAS: 879292-24-7

Formula: C₃₁D₆H₃₃F₃N₃NaO₁₀

Color and Shape: Neat

Molecular weight: 699.677

Ref: TR-S465012

Silodosin-d4 β-D-Glucuronide Sodium Salt

Controlled Product

CAS: 879292-24-7

Formula: C₃₁D₄H₃₅F₃N₃NaO₁₀

Color and Shape: Neat

Molecular weight: 697.665

Ref: TR-S465013

Silodosin b-D-Glucuronide Sodium Salt (>90%)

Controlled Product

CAS: 879292-24-7

Applications Silodosin β-D-Glucuronide Sodium Salt is an adrenergic α1 antagonist and a metabolite of Silodosin (S465000).
References (1) Murata, S., et al.: J. Urol., 164, 578 (2000)(2) Shibata, K., et al.: Mol. Pharmacol., 48, 250 (1995)

Formula: C₃₁H₃₉F₃N₃NaO₁₀

Purity: >90%

Color and Shape: Neat

Molecular weight: 693.64

Ref: TR-S465010

Silodosin b-D-glucuronide sodium salt

CAS: 879292-24-7

Silodosin b-D-glucuronide sodium salt is a glycoconjugate of silodosin and glucuronic acid. It is a white to off-white crystalline powder that is soluble in water. Silodosin b-D-glucuronide sodium salt has been custom synthesized for the modification of saccharides and polysaccharides, which are an important part of our diet. The compound is used as a reagent for click chemistry, glycosylation, and oligosaccharide synthesis.

Formula: C₃₁H₃₉F₃N₃NaO₁₀

Purity: Min. 95%

Color and Shape: Off-White Powder

Molecular weight: 693.64 g/mol

Ref: 3D-MS14905