CAS 88-65-3

2-Bromobenzoic acid

Description:

2-Bromobenzoic acid is an aromatic carboxylic acid characterized by the presence of a bromine atom at the ortho position relative to the carboxylic acid group on the benzene ring. Its molecular formula is C7H6BrO2, and it features a benzene ring substituted with both a bromine atom and a carboxylic acid (-COOH) functional group. This compound typically appears as a white to off-white crystalline solid and is known for its moderate solubility in organic solvents such as ethanol and ether, while being less soluble in water. 2-Bromobenzoic acid is utilized in organic synthesis, particularly in the preparation of various pharmaceuticals and agrochemicals. It can undergo typical reactions of carboxylic acids, including esterification and acid-base reactions. Additionally, the presence of the bromine atom can influence its reactivity and the electronic properties of the molecule, making it a valuable intermediate in synthetic chemistry. Safety precautions should be observed when handling this compound, as it may pose health risks if ingested or inhaled.

Formula: C₇H₅BrO₂

InChI: InChI=1S/C7H5BrO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,(H,9,10)

InChI key: InChIKey=XRXMNWGCKISMOH-UHFFFAOYSA-N

SMILES: C(O)(=O)C1=C(Br)C=CC=C1

Synonyms:

• 2-Brom benzoic acid
• 2-Brombenzoesaure
• 2-Bromobenzoatato
• Acide 2-bromobenzoique
• Acido 2-Bromobenzoico
• Benzoic acid, 2-(bromocarbonyl)-
• Benzoic acid, 2-bromo-
• Benzoic acid, o-bromo-
• Nsc 176122
• Nsc 6976
• O-Bromobenzoic acid

2-Bromobenzoic Acid

CAS: 88-65-3

Formula: C₇H₅BrO₂

Purity: >98.0%(GC)(T)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 201.02

Ref: 3B-B0552

2-Bromobenzoic acid, 98%

CAS: 88-65-3

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Sci

Formula: C₇H₅BrO₂

Purity: 98%

Color and Shape: Powder, White to cream

Molecular weight: 201.02

Ref: 02-A13608

2-Bromobenzoic Acid

CAS: 88-65-3

Formula: C₇H₅BrO₂

Purity: 97%

Color and Shape: Solid

Molecular weight: 201.0174

Ref: IN-DA003364

2-Bromobenzoic acid, min. 98%

CAS: 88-65-3

Formula: C₇H₅BrO₂

Purity: min. 98%

Color and Shape: white to off white solid

Molecular weight: 201.02

Ref: 08-06-0134

2-Bromobenzoic acid

CAS: 88-65-3

2-Bromobenzoic acid

Formula: C₇H₅BrO₂

Purity: 97%

Color and Shape: white solid

Molecular weight: 201.02g/mol

Ref: 54-OR4995

2-Bromobenzoic acid

CAS: 88-65-3

Formula: C₇H₅BrO₂

Molecular weight: 201.02

Ref: 7W-GK2699

2-Bromobenzoic acid

CAS: 88-65-3

Formula: C₇H₅BrO₂

Purity: 97.0%

Color and Shape: Solid, White solid

Molecular weight: 201.019

Ref: 10-F003019

2-Bromobenzoic acid

CAS: 88-65-3

2-Bromobenzoic acid is a sodium salt that has been reported to be used in the treatment of autoimmune diseases and bowel disease. It is a prodrug that is hydrolyzed in vivo to 2-bromophenol, its active form. 2-Bromobenzoic acid has been shown to inhibit the production of inflammatory mediators, such as prostaglandins, leukotrienes, and cytokines by inhibiting cyclooxygenase 1 and 2 enzymes. This drug also inhibits the activation of nuclear factor kappa B (NF-κB) in vitro. 2-Bromobenzoic acid may have an anti-inflammatory effect through its ability to inhibit NF-κB activation by preventing the release of tumor necrosis factor alpha (TNFα).

Formula: C₇H₅BrO₂

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 201.02 g/mol

Ref: 3D-FB02145

2-Bromobenzoic Acid

Controlled Product

CAS: 88-65-3

Applications 2-Bromobenzoic acid is a sterically hindered ortho-bromo compound that is used as a starting material to synthesize quinazolinones (e.g. 8-Hydroxy-2-methyl-4(3H)-quinazolinone [H948330]).
References Liu, X., et al.: Angew. Chem. Int. Edit., 121, 354 (2009); Lu, G., et al.: Tetrahedron Lett., 46, 4255 (2005)

Formula: C₇H₅BrO₂

Color and Shape: Neat

Molecular weight: 201.02

Ref: TR-B680500