CAS 88069-67-4

Pilsicainide

Description:

Pilsicainide is a chemical compound classified as an antiarrhythmic agent, primarily used in the treatment of certain types of cardiac arrhythmias. It belongs to the class of sodium channel blockers, which work by inhibiting the influx of sodium ions during the depolarization phase of the cardiac action potential, thereby stabilizing the cardiac membrane and reducing excitability. Pilsicainide is known for its effectiveness in managing ventricular tachycardia and other arrhythmias. The compound is typically administered in a clinical setting, and its pharmacokinetics involve metabolism primarily in the liver, with renal excretion of its metabolites. Common side effects may include dizziness, hypotension, and potential proarrhythmic effects, necessitating careful monitoring of patients. As with many antiarrhythmic drugs, the therapeutic window is narrow, requiring precise dosing to balance efficacy and safety. Overall, pilsicainide represents a valuable option in the pharmacological management of arrhythmias, although its use must be tailored to individual patient needs and conditions.

Formula: C₁₇H₂₄N₂O

InChI: InChI=1S/C17H24N2O/c1-13-6-3-7-14(2)16(13)18-15(20)12-17-8-4-10-19(17)11-5-9-17/h3,6-7H,4-5,8-12H2,1-2H3,(H,18,20)

InChI key: InChIKey=BCQTVJKBTWGHCX-UHFFFAOYSA-N

SMILES: C(C(NC1=C(C)C=CC=C1C)=O)C23N(CCC2)CCC3

Synonyms:

• 1H-pyrrolizine-7a(5H)-acetamide, N-(2,6-dimethylphenyl)tetrahydro-
• 88069-67-4
• N-(2,6-Dimethylphenyl)tetrahydro-1H-pyrrolizine-7a(5H)-acetamide
• N-(2,6-dimethylphenyl)-2-(tetrahydro-1H-pyrrolizin-7a(5H)-yl)acetamide
• N-(2,6-dimethylphenyl)-8-pyrrolizidineacetamide
• Pilzicainide
• Tetrahydro-1-pyrrolizine-7a(5H)-aceto-2',6'-xylidide
• Pilsicainide

Pilsicainide

CAS: 88069-67-4

Formula: C₁₇H₂₄N₂O

Molecular weight: 272.3853

Ref: IN-DA00GRO8

Pilsicainide Hydrochloride

CAS: 88069-49-2, 88069-67-4

Formula: C₁₇H₂₄N₂O·HCl

Purity: >98.0%(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 308.85

Ref: 3B-P2634

Pilsicainide

CAS: 88069-67-4

Pilsicainide (SUN 1165 free acid) is a potent class Ic antiarrhythmic agent. Pilsicainide is a potent sodium channel blocker[1][2].

Formula: C₁₇H₂₄N₂O

Color and Shape: Solid

Molecular weight: 272.39

Ref: TM-T60482

Pilsicainide

CAS: 88069-67-4

Pilsicainide is an antiarrhythmic drug that belongs to the class of phenylalkylamines. It is used in the treatment of cardiac arrhythmias, such as atrial fibrillation and ventricular tachycardia. Pilsicainide works by blocking the voltage-gated sodium ion channels in the heart, which prevents rapid changes in membrane potential and reduces the likelihood of a reoccurrence of arrhythmias. The drug is also used for bowel disease, where it has been shown to be effective against diseases such as diverticulitis and inflammatory bowel disease. However pilsicainide should not be used for this purpose due to its potential for causing severe side effects such as blood sampling or fibrillation. Pilsicainide is also known to interact with other drugs, namely those that affect locomotor activity or urination (e.g., chlorpromazine).

Formula: C₁₇H₂₄N₂O

Purity: Min. 95%

Molecular weight: 272.4 g/mol

Ref: 3D-NDA06967