CAS 881375-00-4

KU 0060648

Description:

KU 0060648, with the CAS number 881375-00-4, is a small molecule inhibitor primarily known for its role in targeting the mTOR (mechanistic target of rapamycin) signaling pathway. This compound exhibits characteristics typical of kinase inhibitors, including the ability to modulate cellular growth, proliferation, and survival. It is particularly noted for its potential therapeutic applications in cancer treatment, as mTOR is a critical regulator of cell metabolism and growth, often dysregulated in various malignancies. KU 0060648 has been studied for its effects on tumor cell lines and has shown promise in preclinical models. The compound is characterized by its specific binding affinity to the mTOR complex, which can lead to downstream effects on protein synthesis and autophagy. Additionally, it may exhibit selectivity towards certain cancer types, making it a subject of interest in targeted cancer therapies. As with many experimental compounds, further research is necessary to fully understand its pharmacokinetics, efficacy, and safety profile in clinical settings.

Formula: C₃₃H₃₅N₄O₄S

Synonyms:

• CS-768
• 2-(4-Ethylpiperazin-1-yl)-N-(4-(2-morpholino-4-oxo-4H-chromen-8-yl)dibenzo[b,d]thiophen-1-yl)acetamide
• KU0060648;KU 0060648
• KU 0060648 trihydrochloride
• 4-Ethyl-N-[4-[2-(4-morpholinyl)-4-oxo-4H-1-benzopyran-8-yl]-1-dibenzothienyl]-1-piperazineacetamide
• KU 0060648 USP/EP/BP
• KU 0060648
• ku-0060648
• 1-Piperazineacetamide, 4-ethyl-N-[4-[2-(4-morpholinyl)-4-oxo-4H-1-benzopyran-8-yl]-1-dibenzothienyl]-

KU 0060648

CAS: 881375-00-4

Formula: C₃₃H₃₄N₄O₄S

Purity: 98%

Molecular weight: 582.7125

Ref: IN-DA00H0IC

KU-0060648

CAS: 881375-00-4

KU-0060648

Purity: ≥98%

Molecular weight: 582.71g/mol

Ref: 54-BUP01936

KU-0060648

CAS: 881375-00-4

KU-0060648 is a dual inhibitor of DNA-PK and PI3Kα, PI3Kβ, PI3Kδ with IC50 of 8.6 nM and 4 nM, 0.5 nM, 0.1 nM respectively, less inhibition of PI3Kγ.

Formula: C₃₃H₃₄N₄O₄S

Purity: 98.75%

Color and Shape: Solid

Molecular weight: 582.71

Ref: TM-T6557

KU-0060648

CAS: 881375-00-4

Purity: 98%

Molecular weight: 582.23

Ref: 10-F819890

KU-0060648

Controlled Product

CAS: 881375-00-4

Formula: C₃₃H₃₄N₄O₄S

Color and Shape: Neat

Molecular weight: 582.712

Ref: TR-K660420

KU-0060648-D5

Controlled Product

CAS: 881375-00-4

Formula: C₃₃D₅H₂₉N₄O₄S

Color and Shape: Neat

Molecular weight: 587.743

Ref: TR-K660421

KU 0060648

CAS: 881375-00-4

DNA-PK and PI 3-K inhibitor

Formula: C₃₃H₃₄N₄O₄S

Purity: Min. 95%

Molecular weight: 582.71 g/mol

Ref: 3D-BK171533