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CAS 88150-42-9

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Amlodipine

Description:
Amlodipine is a dihydropyridine calcium channel blocker primarily used in the treatment of hypertension and angina. It functions by inhibiting calcium ions from entering vascular smooth muscle and cardiac muscle, leading to vasodilation and reduced blood pressure. Amlodipine is characterized by its chemical formula C20H25ClN2O5S, and it typically appears as a white to off-white crystalline powder. The substance is soluble in organic solvents like ethanol and methanol but has limited solubility in water. Amlodipine exhibits a long half-life, allowing for once-daily dosing, which enhances patient compliance. Its pharmacokinetics are influenced by factors such as age, liver function, and concomitant medications. Common side effects may include peripheral edema, dizziness, and fatigue. As a medication, it is generally well-tolerated, but it is essential for patients to consult healthcare providers for personalized advice and monitoring during treatment.
Formula:C26H31ClN2O8S
InChI:InChI=1/C20H25ClN2O5/c1-4-28-20(25)18-15(11-27-10-9-22)23-12(2)16(19(24)26-3)17(18)13-7-5-6-8-14(13)21/h5-8,17,23H,4,9-11,22H2,1-3H3
InChI key:InChIKey=HTIQEAQVCYTUBX-UHFFFAOYSA-N
SMILES:C(OCC)(=O)C=1C(C(C(OC)=O)=C(C)NC1COCCN)C2=C(Cl)C=CC=C2
Synonyms:
  • (R,S)-Amlodipine
  • 2-(2-Amino-ethoxymethyl)-4-(2-chloro-phenyl)-6-methyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-ethyl ester 5-methyl ester
  • 2-[(2-Aminoethoxy)methyl]-4-(2-chlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridine
  • 3,5-Pyridinedicarboxylic acid, 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl 5-methyl ester
  • 3-Ethyl 5-methyl 2(2-aminoethoxymethyl)-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate
  • 3-O-Ethyl 5-O-methyl 2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
  • Adipin
  • Amlodipine base
  • Amlopres
  • Egiramlon
  • See more synonyms
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