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CAS 88150-47-4

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Amlodipine maleate

Description:
Amlodipine maleate is a pharmaceutical compound primarily used as an antihypertensive agent in the treatment of high blood pressure and angina. It is a calcium channel blocker that works by inhibiting the influx of calcium ions into vascular smooth muscle and cardiac muscle, leading to vasodilation and reduced cardiac workload. The substance is a salt formed from amlodipine, a dihydropyridine derivative, and maleic acid. Amlodipine maleate is typically presented as a white to off-white crystalline powder, which is soluble in water and exhibits stability under normal storage conditions. Its molecular structure allows for effective oral bioavailability, making it suitable for once-daily dosing. The compound is characterized by its relatively long half-life, which contributes to its sustained antihypertensive effects. As with any medication, it is essential to consider potential side effects, interactions, and contraindications when prescribing or using amlodipine maleate.
Formula:C20H25ClN2O5·C4H4O4
InChI:InChI=1S/C20H25ClN2O5.C4H4O4/c1-4-28-20(25)18-15(11-27-10-9-22)23-12(2)16(19(24)26-3)17(18)13-7-5-6-8-14(13)21;5-3(6)1-2-4(7)8/h5-8,17,23H,4,9-11,22H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;2-1-
InChI key:InChIKey=TZNOWAJJWCGILX-BTJKTKAUSA-N
SMILES:C(OCC)(=O)C=1C(C(C(OC)=O)=C(C)NC1COCCN)C2=C(Cl)C=CC=C2.C(=C\C(O)=O)\C(O)=O
Synonyms:
  • 3,5-Pyridinedicarboxylic acid, 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl 5-methyl ester, (+-)-, (Z)-2-butenedioate (1:1)
  • 3,5-Pyridinedicarboxylic acid, 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl 5-methyl ester, (2Z)-2-butenedioate (1:1)
  • 3-Ethyl 5-methyl (+-)-2-((2-aminoethoxy)methyl)-4-(o-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate, maleate (1:1)
  • 3-ethyl 5-methyl 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate (2Z)-but-2-enedioate
  • Amlodipine ( -)-form maleate
  • Amlodipine maleate [USAN]
  • Amvaz
  • Uk 48,340-11
  • Unii-Cq27G2Bzjm
  • Amlodipine maleate
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