CAS 88303-60-0

Losoxantrone

Description:

Losoxantrone is a synthetic anthraquinone derivative that has been primarily investigated for its potential use as an antineoplastic agent in cancer therapy. It exhibits a mechanism of action similar to that of other anthracyclines, primarily through intercalation into DNA, which disrupts the replication and transcription processes, ultimately leading to cell death. Losoxantrone is characterized by its ability to generate reactive oxygen species, contributing to its cytotoxic effects. The compound is typically administered intravenously and has been studied for its efficacy against various types of tumors, including those resistant to conventional therapies. Its pharmacokinetics involve metabolism primarily in the liver, with excretion occurring through the urine. While losoxantrone shows promise in clinical settings, its use may be limited by potential side effects, including cardiotoxicity and myelosuppression, which are common concerns with many chemotherapeutic agents. Ongoing research aims to better understand its therapeutic window and optimize its application in oncology.

Formula: C₂₂H₂₇N₅O₄

InChI: InChI=1S/C22H27N5O4/c28-12-9-23-6-7-25-15-4-5-16-20-19(15)22(31)18-14(2-1-3-17(18)30)21(20)26-27(16)11-8-24-10-13-29/h1-5,23-25,28-30H,6-13H2

InChI key: InChIKey=YROQEQPFUCPDCP-UHFFFAOYSA-N

SMILES: N(CCNCCO)C1=C2C=3C(C=4C(C2=O)=C(O)C=CC4)=NN(CCNCCO)C3C=C1

Synonyms:

• UNII-47KPH00809
• Dibenz[cd,g]indazol-6(2H)-one, 7-hydroxy-2-[2-[(2-hydroxyethyl)amino]ethyl]-5-[[2-[(2-hydroxyethyl)amino]ethyl]amino]-
• Losoxantrone [INN:BAN]
• 7-hydroxy-2-{2-[(2-hydroxyethyl)amino]ethyl}-5-({2-[(2-hydroxyethyl)amino]ethyl}amino)dibenzo[cd,g]indazol-6(2H)-one
• 7-Hydroxy-2-[2-[(2-hydroxyethyl)amino]ethyl]-5-[[2-[(2-hydroxyethyl)amino]ethyl]amino]dibenz[cd,g]indazol-6(2H)-one
• Biantrazole
• Anthra(1,9-cd)pyrazol-6(2H)-one, 7-hydroxy-2-(2-((2-hydroxyethyl)amino)ethyl)-5-((2-((2-hydroxyethyl)amino)ethyl)amino)-
• C 1941
• Bis-alkylamino anthrapyrazole
• Anthra[1,9-cd]pyrazol-6(2H)-one, 7-hydroxy-2-[2-[(2-hydroxyethyl)amino]ethyl]-5-[[2-[(2-hydroxyethyl)amino]ethyl]amino]-