CAS 88411-77-2

(6β,11β,16α)-16,17-[Butylidenebis(oxy)]-6,11,21-trihydroxypregna-1,4-diene-3,20-dione

Description:

The chemical substance known as "(6β,11β,16α)-16,17-[Butylidenebis(oxy)]-6,11,21-trihydroxypregna-1,4-diene-3,20-dione," with the CAS number 88411-77-2, is a synthetic steroid compound. It features a complex structure characterized by multiple hydroxyl groups, which contribute to its potential biological activity. The presence of the butylidene group indicates that it may exhibit unique reactivity and stability compared to other steroids. This compound is likely to interact with biological systems, possibly influencing hormonal pathways or exhibiting anti-inflammatory properties. Its structural modifications, including the diene and ketone functionalities, suggest potential applications in pharmacology, particularly in the development of therapeutic agents. As with many steroid derivatives, the specific characteristics such as solubility, melting point, and biological activity would depend on the precise arrangement of its functional groups and overall conformation. Further research would be necessary to fully elucidate its properties and potential uses in medicine or biochemistry.

Formula: C₂₅H₃₄O₇

InChI: InChI=1S/C25H34O7/c1-4-5-21-31-20-10-15-14-9-17(28)16-8-13(27)6-7-23(16,2)22(14)18(29)11-24(15,3)25(20,32-21)19(30)12-26/h6-8,14-15,17-18,20-22,26,28-29H,4-5,9-12H2,1-3H3/t14-,15-,17+,18-,20+,21?,22+,23-,24-,25+/m0/s1

InChI key: InChIKey=JBVVDXJXIDYDMF-GVTADUIWSA-N

SMILES: C(CO)(=O)[C@]12[C@]3(C)[C@@](C[C@]1(OC(CCC)O2)[H])([C@]4([C@]([C@@H](O)C3)([C@]5(C)C([C@H](O)C4)=CC(=O)C=C5)[H])[H])[H]

Synonyms:

• (6β,11β,16α)-16,17-[Butylidenebis(oxy)]-6,11,21-trihydroxypregna-1,4-diene-3,20-dione
• 6b-Hydroxybudesonide
• Pregna-1,4-diene-3,20-dione, 16,17-[butylidenebis(oxy)]-6,11,21-trihydroxy-, (6β,11β,16α)-

6β-Hydroxybudesonide ((2R,6aR,6bS,7S,8aS,8bS,11aR,12aS,12bS)-2,7-dihydroxy-8b-(2-hydroxyacetyl)-6a,8a-dimethyl-10-propyl-1,2,6a,6b,7,8,8a,8b,11a,12,12a,12b-dodecahydro-4H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-4-one)

CAS: 88411-77-2

Heterocyclic compounds with oxygen hetero-atom(s) only, nesoi

Formula: C₂₅H₃₄O₇

Color and Shape: White Off-White Solid

Molecular weight: 446.23045

Ref: 45-1A01400

6-β-Hydroxy Budesonide (Mixture of Diastereomers)

CAS: 88411-77-2

Formula: C₂₅H₃₄O₇

Color and Shape: White To Off-White Solid

Molecular weight: 446.54

Ref: 4Z-B-037

6β-Hydroxy Budesonide-d8

Controlled Product

CAS: 88411-77-2

Applications A labelled metabolite of Budesonide (B689490), a non-halogenated glucocorticoid related to triamcinolone hexacetonide. Used as an antiinflammatory agent.
References Ryrfeldt., A., et a.: J. Steroid Biochem., 10, 317 (1979), Roth, G., et al.: J. Pharm. Sci., 69, 766 (1980), Edsbaecker, S., et al.: Drug Metab. Dispos., 15, 412 (1987),

Formula: C₂₅H₂₆D₈O₇

Purity: ~90%

Color and Shape: Neat

Molecular weight: 454.58

Ref: TR-H830352

6β-Hydroxy Budesonide

Controlled Product

CAS: 88411-77-2

Formula: C₂₅H₃₄O₇

Color and Shape: White To Light Yellow

Molecular weight: 446.53

Ref: TR-H830350

6b-Hydroxy budesonide

CAS: 88411-77-2

6b-Hydroxy budesonide is a drug that is metabolized to budesonide, which is a potent glucocorticoid. The pharmacokinetic profile of 6b-hydroxy budesonide was studied in animals and humans. This drug has minimal biliary excretion and is extensively metabolized by the liver. It has been shown to have anti-inflammatory effects, with cyp3a substrates being involved in its metabolism. 6b-Hydroxy budesonide binds to the glucocorticoid receptor, leading to DNA transcription and protein synthesis inhibition. 6b-Hydroxy budesonide has been used for the treatment of cirrhosis, as it helps to reduce the severity of symptoms such as nausea and vomiting.

Formula: C₂₅H₃₄O₇

Purity: Min. 95%

Molecular weight: 446.53 g/mol

Ref: 3D-FH23924

6β-Hydroxybudesonide

CAS: 88411-77-2

Formula: C₂₅H₃₄O₇

Molecular weight: 446.54

Ref: ST-EA-CP-B19020