CAS 88416-50-6

Disodium clodronate tetrahydrate

Description:

Disodium clodronate tetrahydrate is a bisphosphonate compound primarily used in the treatment of bone disorders, particularly in conditions like osteoporosis and metastatic bone disease. Its chemical formula is C5H8Cl2N2Na2O8P2·4H2O, indicating that it contains two sodium ions, four water molecules, and a clodronate moiety. The substance is characterized by its ability to inhibit bone resorption by osteoclasts, which are cells responsible for bone breakdown. Disodium clodronate tetrahydrate is typically administered intravenously and is known for its relatively low toxicity compared to other bisphosphonates. It is soluble in water, which facilitates its use in clinical settings. The compound's stability and efficacy make it a valuable therapeutic agent in managing hypercalcemia associated with malignancies and in preventing skeletal-related events in cancer patients. As with any medication, it is essential to monitor for potential side effects, including gastrointestinal disturbances and renal function changes.

Formula: CH₄Cl₂O₆P₂·4H₂O·2Na

InChI: InChI=1S/CH4Cl2O6P2.2Na.4H2O/c2-1(3,10(4,5)6)11(7,8)9;;;;;;/h(H2,4,5,6)(H2,7,8,9);;;4*1H2

InChI key: InChIKey=MBJMCOJMDMARNB-UHFFFAOYSA-N

SMILES: C(P(=O)(O)O)(P(=O)(O)O)(Cl)Cl.[Na].O

Synonyms:

• (Dichloromethylene)bisphosphonic acid disodium salt tetrahydrate
• Clodronate Disodium
• Phosphonic acid, (dichloromethylene)bis-, disodium salt, tetrahydrate
• Phosphonic acid, P,P′-(dichloromethylene)bis-, sodium salt, hydrate (1:2:4)
• Disodium clodronate tetrahydrate

Phosphonic acid, (dichloromethylene)bis-, disodium salt, tetrahydrate

CAS: 88416-50-6

Formula: CH₁₀Cl₂Na₂O₁₀P₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 360.9172

Ref: IN-DA00IF36

Disodium Clodronate Tetrahydrate

CAS: 88416-50-6

Disodium Clodronate Tetrahydrate

Purity: 98%

Molecular weight: 288.85g/mol

Ref: 54-OR1013003

Clodronate disodium tetrahydrate

CAS: 88416-50-6

Clodronate disodium tetrahydrate

Purity: ≥95%

Molecular weight: 360.92g/mol

Ref: 54-BUP17964

Clodronate disodium salt hydrate

CAS: 88416-50-6

Formula: CH₂Cl₂Na₂O₆P₂·4H₂O

Purity: 98.0 - 102.0 % (anhydrous basis)

Color and Shape: White or off-white crystalline powder

Molecular weight: 288.86 (anhydrous)

Ref: 7W-GP6103

Disodium Clodronate Tetrahydrate

CAS: 22560-50-5, 88416-50-6

Formula: CH₂Cl₂Na₂O₆P₂·4H₂O

Purity: >95.0%(T)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 360.91

Ref: 3B-D4160

Clodronate disodium tetrahydrate

CAS: 88416-50-6

Clodronate disodium tetrahydrate (Clastoban) inhibits bone resorption and soft tissue calcification.

Formula: CH₁₀Cl₂Na₂O₁₀P₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 360.92

Ref: TM-T3280

Disodium clodronate tetrahydrate

CAS: 88416-50-6

Disodium clodronate tetrahydrate is a water-soluble salt of the active form of clodronic acid, which has been shown to have anti-inflammatory activity. It is used in the treatment of breast cancer, as well as bowel disease. Disodium clodronate tetrahydrate inhibits basic protein synthesis and the production of pro-inflammatory cytokines by toll-like receptor 4 (TLR4) on polymorphonuclear leucocytes (PMN). This drug has also been shown to inhibit the enzyme activities of sodium salts, but not other enzymes such as phosphofructokinase or lactate dehydrogenase. Disodium clodronate tetrahydrate is also used in analytical methods that are based on measuring changes in the migration rate of proteins.

Formula: CH₂Cl₂Na₂O₆P₂·4H₂O

Color and Shape: White Powder

Molecular weight: 360.92 g/mol

Ref: 3D-FD75417