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CAS 885060-09-3

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Filanesib

Description:
Filanesib, also known by its development code ARRY-520, is a small molecule inhibitor primarily targeting the kinesin spindle protein (KSP), which plays a crucial role in mitosis. This compound is characterized by its potential application in cancer therapy, particularly for hematological malignancies and solid tumors. Filanesib disrupts the normal function of KSP, leading to cell cycle arrest and subsequent apoptosis in cancer cells. It is typically administered intravenously and has been evaluated in clinical trials for its efficacy and safety profile. The substance is known for its selective action against cancer cells while sparing normal cells, which is a significant advantage in reducing side effects associated with traditional chemotherapy. Additionally, Filanesib's pharmacokinetics, including absorption, distribution, metabolism, and excretion, are important factors in its therapeutic effectiveness. As research continues, Filanesib represents a promising avenue in targeted cancer therapies, contributing to the ongoing efforts to improve treatment outcomes for patients with various types of cancer.
Formula:C20H22F2N4O2S
InChI:InChI=1S/C20H22F2N4O2S/c1-25(28-2)19(27)26-20(11-6-12-23,14-7-4-3-5-8-14)29-18(24-26)16-13-15(21)9-10-17(16)22/h3-5,7-10,13H,6,11-12,23H2,1-2H3/t20-/m0/s1
InChI key:InChIKey=LLXISKGBWFTGEI-FQEVSTJZSA-N
SMILES:C(CCN)[C@@]1(N(C(N(OC)C)=O)N=C(S1)C2=C(F)C=CC(F)=C2)C3=CC=CC=C3
Synonyms:
  • (2S)-2-(3-Aminopropyl)-5-(2,5-difluorophenyl)-N-methoxy-N-methyl-2-phenyl-1,3,4-thiadiazole-3(2H)-carboxamide
  • (2S)-2-(3-Aminopropyl)-5-(2,5-difluorophenyl)-N-methoxy-N-methyl-2-phenyl-1,3,4-thiadiazole-3-carboxamide
  • Arry 520
  • Filanesib
  • 1,3,4-Thiadiazole-3(2H)-carboxamide, 2-(3-aminopropyl)-5-(2,5-difluorophenyl)-N-methoxy-N-methyl-2-phenyl-, (2S)-
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Found 3 products.