CAS 885325-71-3

MK-8745

Description:

MK-8745, with the CAS number 885325-71-3, is a small molecule that functions as an antiviral agent, specifically targeting the human immunodeficiency virus (HIV). It belongs to a class of compounds known as non-nucleoside reverse transcriptase inhibitors (NNRTIs), which work by inhibiting the reverse transcriptase enzyme, crucial for the replication of HIV. MK-8745 has demonstrated efficacy in preclinical and clinical studies, showing potential for use in HIV treatment regimens. The compound is characterized by its ability to bind to the reverse transcriptase enzyme, thereby preventing the conversion of viral RNA into DNA, a key step in the viral life cycle. Its pharmacokinetic properties, including absorption, distribution, metabolism, and excretion, are essential for determining its suitability for therapeutic use. Additionally, MK-8745 has been evaluated for its safety profile and potential side effects, which are critical considerations in the development of antiviral therapies. Overall, MK-8745 represents a promising candidate in the ongoing efforts to combat HIV/AIDS.

mk8745

CAS: 885325-71-3

Formula: C₂₀H₁₉ClFN₅OS

Purity: 98%

Color and Shape: Solid

Molecular weight: 431.9142

Ref: IN-DA00GU4F

MK-8745

CAS: 885325-71-3

MK-8745

Purity: ≥98%

Molecular weight: 431.91g/mol

Ref: 54-BUP14236

MK-8745

CAS: 885325-71-3

MK-8745 is a potent and selective Aurora A inhibitor.

Formula: C₂₀H₁₉ClFN₅OS

Purity: 99.09% - 99.79%

Color and Shape: Solid

Molecular weight: 431.91

Ref: TM-T2471

MK-8745

Controlled Product

CAS: 885325-71-3

Applications MK-8745 is a potent and selective Aurora A kinase inhibitor that induces apoptotic cell death in a p53-dependent manner when tested in vitro in cell lines of multiple lineages.
References Nair, J.S., et al.: Cell Cycle, 11, 807 (2012); Chowdhury, A., et al.: Leukemia Lymphoma, 53, 462 (2012)

Formula: C₂₀H₁₉ClFN₅OS

Color and Shape: Neat

Molecular weight: 431.91

Ref: TR-M425040