CAS 88546-74-1

H-D-Pro-Phe-Arg-chloromethylketone

Description:

H-D-Pro-Phe-Arg-chloromethylketone, with the CAS number 88546-74-1, is a synthetic peptide derivative that serves as a potent inhibitor of certain proteolytic enzymes, particularly serine proteases. This compound is characterized by its unique structure, which includes a chloromethylketone moiety that is crucial for its inhibitory activity. The presence of the amino acid residues D-Proline (D-Pro), Phenylalanine (Phe), and Arginine (Arg) contributes to its specificity and binding affinity for target enzymes. Typically, such compounds are utilized in biochemical research to study enzyme mechanisms and to develop therapeutic agents. The chloromethylketone functionality allows for covalent modification of the active site of serine proteases, effectively blocking their activity. As a peptide derivative, it may exhibit properties such as solubility in polar solvents and potential bioactivity, making it of interest in pharmacological studies. However, handling and usage require caution due to its reactive nature and potential toxicity.

Formula: C₂₁H₃₁ClN₆O₃

H-D-Pro-Phe-Arg-chloromethylketone

CAS: 88546-74-1

D-PFR-CMK, inhibitor of coagulation factor XII and plasma kallikrein.

Formula: C₂₁H₃₁ClN₆O₃

Purity: 96.0%

Color and Shape: White Powder

Molecular weight: 450.97

Ref: 01-4013721

D-Pro-Phe-Arg-Chloromethylketone

CAS: 88546-74-1

Formula: C₂₁H₃₁ClN₆O₃

Purity: 98%

Molecular weight: 450.9622

Ref: IN-DA004FQC

D-Pro-Phe-Arg-Chloromethylketone

CAS: 88546-74-1

D-Pro-Phe-Arg-Chloromethylketone, an inhibitor of coagulation factor XII and plasma kallikrein, is significant in the regulation of thrombosis and inflammation

Formula: C₂₁H₃₁ClN₆O₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 450.96

Ref: TM-T80095

H-D-Pro-Phe-Arg-chloromethylketone trifluoroacetate salt

CAS: 88546-74-1

H-D-Pro-Phe-Arg-chloromethylketone trifluoroacetate salt is a polyvalent antivenom that is used in the treatment of snakebites and insect stings. It has been shown to be effective in the treatment of life-threatening envenomations, including bites from cobras and other rattlesnakes. This drug is not active against nonactivated venom, such as those from bees or spiders. H-D-Pro-Phe-Arg-chloromethylketone trifluoroacetate salt binds to the cytolysin, which prevents its activity by inactivating it. The drug also has a vasoconstrictive effect, which limits blood flow to tissues and may reduce tissue damage caused by venom toxins.

Formula: C₂₁H₃₁ClN₆O₃

Purity: Min. 95%

Molecular weight: 450.96 g/mol

Ref: 3D-FP111023