CAS 887148-69-8

Monepantel

Description:

Monepantel is a synthetic anthelmintic agent primarily used in veterinary medicine for the treatment of parasitic infections in livestock, particularly in sheep. It belongs to a novel class of compounds known as amino-acetonitrile derivatives. Monepantel acts by selectively targeting specific nicotinic acetylcholine receptors in nematodes, leading to paralysis and death of the parasites. The substance is characterized by its high efficacy against a broad spectrum of gastrointestinal nematodes, including those resistant to other anthelmintics. Monepantel is typically administered orally and is known for its favorable safety profile in treated animals. Its chemical structure includes a unique amino-acetonitrile moiety, which contributes to its mechanism of action. Additionally, Monepantel is subject to regulatory oversight to ensure its safe use in food-producing animals, with guidelines established for withdrawal periods before slaughter to minimize residues in meat products. Overall, Monepantel represents an important advancement in the management of parasitic infections in livestock, contributing to improved animal health and productivity.

Formula: C₂₀H₁₃F₆N₃O₂S

InChI: InChI=1S/C20H13F6N3O2S/c1-18(10-28,11-31-16-8-12(9-27)2-7-15(16)19(21,22)23)29-17(30)13-3-5-14(6-4-13)32-20(24,25)26/h2-8H,11H2,1H3,(H,29,30)/t18-/m0/s1

InChI key: InChIKey=WTERNLDOAPYGJD-SFHVURJKSA-N

SMILES: O(C[C@@](NC(=O)C1=CC=C(SC(F)(F)F)C=C1)(C#N)C)C2=C(C(F)(F)F)C=CC(C#N)=C2

Synonyms:

• Benzamide, N-[(1S)-1-cyano-2-[5-cyano-2-(trifluoromethyl)phenoxy]-1-methylethyl]-4-[(trifluoromethyl)thio]-
• FXFFSR DVMX1& CN& 1OR CCN FXFFF & & S Form
• Monepantel
• N-[(1S)-1-Cyano-2-[5-cyano-2-(trifluoromethyl)phenoxy]-1-methylethyl]-4-[(trifluoromethyl)thio]benzamide
• Zolvix

BenzaMide, N-[(1S)-1-cyano-2-[5-cyano-2-(trifluoroMethyl)phenoxy]-1-Methylethyl]-4-[(trifluoroMethyl)thio]-

CAS: 887148-69-8

Formula: C₂₀H₁₃F₆N₃O₂S

Purity: %

Color and Shape: Solid

Molecular weight: 473.3915

Ref: IN-DA00H38S

Monepantel

CAS: 887148-69-8

Formula: C₂₀H₁₃F₆N₃O₂S

Color and Shape: White To Off-White Solid

Molecular weight: 473.39

Ref: 4Z-M-556

Monepantel

CAS: 887148-69-8

Monepantel

Purity: ≥98%

Molecular weight: 473.39g/mol

Ref: 54-BUP09489

Monepantel-d5

CAS: 887148-69-8

Formula: C₂₀H₈F₆N₃O₂SD₅

Molecular weight: 478.43

Ref: 4Z-M-552

Monepantel

CAS: 887148-69-8

Monepantel (AAD1566) is an organic anthelmintic and an antagonist of nAChRs from roundworms and esophageostomy.

Formula: C₂₀H₁₃F₆N₃O₂S

Purity: 99.83%

Color and Shape: White Powder

Molecular weight: 473.39

Ref: TM-T16126

Monepantel

CAS: 887148-69-8

Applications Monepantel is a recently discovered anthelmitic used in the treatment of parasitic nematodes via stun or kill without damaging the host entity.
References Baur, R. et al.: Mol. Pharm., 87, 96 (2015); Stuchlikova, L. et al.: Chemico. Biol. Interact., 227, 63 (2015);

Formula: C₂₀H₁₃F₆N₃O₂S

Color and Shape: White To Off-White

Molecular weight: 473.39

Ref: TR-M515800

Monepantel

CAS: 887148-69-8

Monepantel is a drug that has been shown to have anthelmintic activity in vitro and in vivo models. It binds to the cation channel of nematode worms, which prevents the flow of ions across the membrane and leads to paralysis and death of the worm. Monepantel also has shown to be clinically relevant for the treatment of microbial infections in humans. It inhibits an enzyme that catalyzes the synthesis of phospholipids, which are vital for cell membranes. Monepantel binds with high affinity to bacterial cells, but not mammalian cells. This drug is broken down by chemical stability and has a short half-life in vivo because it is excreted through urine.

Formula: C₂₀H₁₃F₆N₃O₂S

Purity: 95%

Molecular weight: 473.39 g/mol

Ref: 3D-MKB14869