CAS 887375-26-0

Mapracorat

Description:

Mapracorat is a synthetic corticosteroid that is primarily used for its anti-inflammatory properties. It is characterized by its selective action on glucocorticoid receptors, which allows it to exert therapeutic effects while minimizing some of the side effects commonly associated with traditional corticosteroids. The compound is known for its ability to reduce inflammation and modulate immune responses, making it useful in treating various inflammatory conditions. Mapracorat has been studied for its potential applications in dermatology and ophthalmology, particularly in conditions like allergic conjunctivitis and other inflammatory skin disorders. Its pharmacokinetic profile suggests a favorable absorption and distribution in target tissues, contributing to its efficacy. Additionally, Mapracorat's chemical structure includes specific functional groups that enhance its potency and selectivity. As with any corticosteroid, careful consideration of dosage and duration of treatment is essential to mitigate potential side effects, such as adrenal suppression or local irritation. Overall, Mapracorat represents a promising option in the realm of anti-inflammatory therapies.

Formula: C₂₅H₂₆F₄N₂O₂

InChI: InChI=1S/C25H26F4N2O2/c1-15-7-8-18-20(5-4-6-21(18)31-15)30-14-24(32,25(27,28)29)13-23(2,3)19-12-17(26)11-16-9-10-33-22(16)19/h4-8,11-12,30,32H,9-10,13-14H2,1-3H3/t24-/m1/s1

InChI key: InChIKey=VJGFOYBQOIPQFY-XMMPIXPASA-N

SMILES: C(C[C@@](CNC=1C2=C(C=CC1)N=C(C)C=C2)(C(F)(F)F)O)(C)(C)C3=C4C(=CC(F)=C3)CCO4

Synonyms:

• Mapracorat
• BOL 303242X
• ZK 245186
• 7-Benzofuranpropanol, 5-fluoro-2,3-dihydro-γ,γ-dimethyl-α-[[(2-methyl-5-quinolinyl)amino]methyl]-α-(trifluoromethyl)-, (αR)-
• (αR)-5-Fluoro-2,3-dihydro-γ,γ-dimethyl-α-[[(2-methyl-5-quinolinyl)amino]methyl]-α-(trifluoromethyl)-7-benzofuranpropanol

Mapracorat

CAS: 887375-26-0

Mapracorat (ZK-245186, BOL-303242X) is a selective glucocorticoid receptor agonist,anti-inflammatory agent for atopic dermatitis and allergic conjunctivitis.

Formula: C₂₅H₂₆F₄N₂O₂

Color and Shape: Solid

Molecular weight: 462.48

Ref: TM-T13451L