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CAS 88741-92-8

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2H-1,2-Benzothiazine-3-carboxylicacid, 4-hydroxy-2-methyl-, 1,1-dioxide

Description:
2H-1,2-Benzothiazine-3-carboxylic acid, 4-hydroxy-2-methyl-, 1,1-dioxide, commonly referred to by its CAS number 88741-92-8, is a chemical compound characterized by its unique bicyclic structure that incorporates both benzothiazine and carboxylic acid functionalities. This compound typically exhibits properties such as moderate solubility in polar solvents due to the presence of the carboxylic acid and hydroxyl groups, which can engage in hydrogen bonding. The 1,1-dioxide moiety contributes to its stability and reactivity, potentially influencing its biological activity. The presence of the methyl group at the 2-position of the benzothiazine ring can affect its steric and electronic properties, which may play a role in its interactions with biological targets. This compound may be of interest in medicinal chemistry and pharmacology, particularly for its potential therapeutic applications. However, specific data regarding its toxicity, environmental impact, and detailed reactivity would require further investigation and analysis.
Formula:C10H9NO5S
Synonyms:
  • 2-Methyl-4-hydroxy-2h-1,2-benzothiazine-3-carboxylic acid-1,1-dioxide
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  • 4-Hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxylic Acid, 1,1-Dioxide
    TRC
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    4-Hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxylic Acid, 1,1-Dioxide

    Controlled Product
    CAS:
    <p>Applications 4-Hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxylic Acid, 1,1-Dioxide could be useful in analytical studies that look to enhance chemical stability of drug substances with high melting points by melt extrusion. 4-Hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxylic Acid, 1,1-Dioxide is similar to Methyl 4-Hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxylate 1,1-Dioxide (M312845(P)), which is an impurity found in Meloxicam (M216100(P)). Meloxicam was specifically used in these melt extrusion studies.<br>References Haser, A., et al.: Int. J. Pharm. (Amsterdam, Neth.), 524, 55 (2017); Lombardino, J., et al.: J. Med. Chem., 14, 1171 (1971); Shin, S., et al.: Drug Dev. Ind. Pharm., 26, 563 (2000);<br></p>
    Formula:C10H9NO5S
    Color and Shape:Neat
    Molecular weight:255.247

    Ref: TR-H887410

    100mg
    2,087.00€