CAS 88768-40-5

Cilazapril

Description:

Cilazapril is an angiotensin-converting enzyme (ACE) inhibitor primarily used in the treatment of hypertension and heart failure. It is a prodrug that is converted in the body to its active form, cilazaprilat, which exerts its pharmacological effects by inhibiting the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor. This action leads to vasodilation, reduced blood pressure, and decreased workload on the heart. Cilazapril is characterized by its chemical formula, which includes elements such as carbon, hydrogen, nitrogen, and oxygen, reflecting its complex structure. It is typically administered orally and is known for its relatively long half-life, allowing for once-daily dosing. Common side effects may include dizziness, fatigue, and cough, while serious adverse effects can involve renal impairment and hyperkalemia. As with other ACE inhibitors, cilazapril should be used with caution in patients with a history of angioedema or those who are pregnant. Overall, cilazapril is an effective medication for managing cardiovascular conditions, contributing to improved patient outcomes.

Formula: C₁₆H₂₅N₂NaO₅S

InChI: InChI=1/C22H31N3O5/c1-2-30-22(29)18(13-12-16-8-4-3-5-9-16)23-17-10-6-14-24-15-7-11-19(21(27)28)25(24)20(17)26/h3-5,8-9,17-19,23H,2,6-7,10-15H2,1H3,(H,27,28)/t17-,18-,19-/m0/s1

InChI key: InChIKey=HHHKFGXWKKUNCY-FHWLQOOXSA-N

SMILES: C(O)(=O)[C@H]1N2N(CCC1)CCC[C@H](N[C@@H](CCC3=CC=CC=C3)C(OCC)=O)C2=O

Synonyms:

• (1S,9S)-9-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]octahydro-10-oxo-6H-pyridazino[1,2-a][1,2]diazepine-1-carboxylic acid
• (1S,9S)-9-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}-10-oxooctahydro-6H-pyridazino[1,2-a][1,2]diazepine-1-carboxylic acid
• 6H-Pyridazino[1,2-a][1,2]diazepine-1-carboxylic acid, 9-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]octahydro-10-oxo-, (1S,9S)-
• 6H-Pyridazino[1,2-a][1,2]diazepine-1-carboxylic acid, 9-[[1-(ethoxycarbonyl)-3-phenylpropyl]amino]octahydro-10-oxo-
• 6H-Pyridazino[1,2-a][1,2]diazepine-1-carboxylic acid, 9-[[1-(ethoxycarbonyl)-3-phenylpropyl]amino]octahydro-10-oxo-, [1S-[1α,9α(R*)]]-
• Cilazapril anhydrous
• Inhibace
• Ro 31-2848
• Vascace
• Yipingshu
• Cilazapril
• CILASTATIN NA
• (1S,9S)-9-[[(S)-1-Ethoxycarbonyl-3-phenylpropyl]amino]octahydro-10-oxo-6H-pyridazino[1,2-a][1,2]diazepine-1-carboxylic acid
• sodium 7-(2-amino-2-carboxy-ethyl)sulfanyl-2-(2,2-dimethylcyclopropyl)carbonylamino-hept-2-enoate
• CILASTATIN SODIUM
• (1S,9S)-9-[(S)-1-Ethoxycarbonyl-3-phenylpropylamino]-10-oxoperhydropyridazino[1,2-a][1,2]diazepine-1-carboxylic acid
• sodium hydrogen 7-[(2-amino-2-carboxylatoethyl)thio]-2-[[(2,2-dimethylcyclopropyl)carbonyl]amino]hept-2-enoate
• (1S,9S)-9-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-10-oxooctahydro-6H-pyridazino[1,2-a][1,2]diazepine-1-carboxylic acid

6H-Pyridazino[1,2-a][1,2]diazepine-1-carboxylicacid, 9-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]octahydro-10-oxo-,(1S,9S)-

CAS: 88768-40-5

Formula: C₂₂H₃₁N₃O₅

Purity: 98%

Color and Shape: Solid

Molecular weight: 417.4986

Ref: IN-DA008B5L

Cilazapril

CAS: 88768-40-5

Formula: C₂₂H₃₃N₃O₆

Molecular weight: 435.51

Ref: 7W-GP2973

Cilazapril

CAS: 88768-40-5

Formula: C₂₂H₃₁N₃O₅

Color and Shape: White To Off-White Solid

Molecular weight: 417.51

Ref: 4Z-C-061

Cilazapril-d5

CAS: 88768-40-5

Formula: C₂₂H₂₆D₅N₃O₅

Molecular weight: 422.54

Ref: 4Z-C-063

Cilazapril

Controlled Product

CAS: 88768-40-5

Applications An ACE inhibitor. Hydrolyzed in vivo to the active diacid metabolite (Cilazaprilat). Antihypertensive.
References Natoff, I.L., et al.: J. Cardiovasc. Pharmacol., 7, 569 (1985), Szucs, T., et al.: Drugs, 41, Suppl.1, 18 (1991), Pordy, R.C., et al.: Cardiology, 86, 41 (1995),

Formula: C₂₂H₃₁N₃O₅

Color and Shape: White

Molecular weight: 417.50

Ref: TR-C441200

Cilazapril-d5

Controlled Product

CAS: 88768-40-5

Formula: C₂₂D₅H₂₆N₃O₅

Color and Shape: Neat

Molecular weight: 422.529

Ref: TR-C441202

Cilazapril

CAS: 88768-40-5

Cilapzapril is a prodrug form that belongs to the group of angiotensin converting enzyme inhibitors, also known as ACE inhibitors. It acts as antihypertensive and inhibits the production angiotensin, a hormone that casused an increase in blood pressure due to blood vessels constriction. Cilapzapril is similar to other compounds as propranolol, atenolol, hydrochlorothiazide, captopril, enalapril, but recent studies has shown that it can also moderate the proliferative response in vessels after vascular injury. Cilapzapril is also available as cilapzapril monohydrate.

Formula: C₂₂H₃₁N₃O₅

Purity: Min. 95%

Molecular weight: 417.5 g/mol

Ref: 3D-FC20433