CAS 888216-25-9

Ganetespib

Description:

Ganetespib is a small molecule inhibitor primarily known for its role as a heat shock protein 90 (HSP90) inhibitor. It is classified as an antineoplastic agent, which means it is used in cancer treatment due to its ability to disrupt the function of HSP90, a chaperone protein that assists in the proper folding and stabilization of various client proteins involved in cancer cell proliferation and survival. Ganetespib has shown potential in preclinical and clinical studies for treating various types of cancers, including lung cancer and other solid tumors. The compound is characterized by its specific molecular structure, which allows it to bind to the ATP-binding site of HSP90, thereby inhibiting its activity. This inhibition leads to the degradation of client proteins that are crucial for tumor growth and survival. Ganetespib is typically administered via intravenous injection and has been the subject of various clinical trials to evaluate its efficacy and safety profile in cancer therapy.

Formula: C₂₀H₂₀N₄O₃

Synonyms:

• 3-(2,4-Dihydroxy-5-isopropylphenyl)-4-(1-methylindol-5-yl)-5-hydroxy-4H-1,2,4-triazole
• 3H-1,2,4-Triazol-3-one, 5-[2,4-dihydroxy-5-(1-methylethyl)phenyl]-2,4-dihydro-4-(1-methyl-1H-indol-5-yl)-

Ganetespib

CAS: 888216-25-9

Formula: C₂₀H₂₀N₄O₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 364.3978

Ref: IN-DA00GU3I

Ganetespib

CAS: 888216-25-9

Ganetespib

Purity: ≥95%

Molecular weight: 364.4g/mol

Ref: 54-BUP15462

Ganetespib

CAS: 888216-25-9

Ganetespib (STA-9090) is a synthetic small-molecule inhibitor of heat shock protein 90 (Hsp90) with potential antineoplastic activity.

Formula: C₂₀H₂₀N₄O₃

Purity: 98% - 99.95%

Color and Shape: Solid

Molecular weight: 364.4

Ref: TM-T2309

2,4-Dihydro-5-[2,4-dihydroxy-5-isopropylphenyl]-4-(1-methyl-1H-indol-5-yl)-3H-1,2,4-triazol-3-one

CAS: 888216-25-9

2,4-Dihydro-5-[2,4-dihydroxy-5-isopropylphenyl]-4-(1-methyl-1H-indol-5-yl)-3H-1,2,4-triazol-3-one

Formula: C₂₀H₂₀N₄O₃

Purity: By hplc: 98% (Typical Value in Batch COA)

Color and Shape: white solid

Molecular weight: 364.40g/mol

Ref: 54-OR305233

GANETESPIB

CAS: 888216-25-9

Purity: 95.0%

Color and Shape: Solid

Molecular weight: 364.405

Ref: 10-F468363

Ganetespib

CAS: 888216-25-9

Heat shock protein 90 (HSP90) inhibitor

Formula: C₂₀H₂₀N₄O₃

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 364.4 g/mol

Ref: 3D-FG137675