CAS 88847-89-6

8-Hydroxy-2′-deoxyguanosine

Description:

8-Hydroxy-2′-deoxyguanosine (8-OHdG) is a modified nucleoside that serves as a biomarker for oxidative stress and DNA damage. It is formed when reactive oxygen species (ROS) interact with deoxyguanosine, leading to the oxidation of the guanine base. This compound is characterized by the presence of a hydroxyl group at the 8-position of the guanine ring, which distinguishes it from its unmodified counterpart. 8-OHdG is soluble in water and exhibits a tendency to form stable adducts with DNA, potentially leading to mutagenic effects if not repaired. Its presence in biological samples, such as urine and tissues, is often measured to assess oxidative damage and has implications in various diseases, including cancer and neurodegenerative disorders. Analytical techniques such as high-performance liquid chromatography (HPLC) and mass spectrometry are commonly employed to quantify 8-OHdG levels. Overall, 8-Hydroxy-2′-deoxyguanosine is a significant marker in the study of oxidative stress and its role in cellular damage and disease progression.

Formula: C₁₀H₁₃N₅O₅

InChI: InChI=1S/C10H13N5O5/c11-9-13-7-6(8(18)14-9)12-10(19)15(7)5-1-3(17)4(2-16)20-5/h3-5,16-17H,1-2H2,(H,12,19)(H3,11,13,14,18)/t3-,4+,5+/m0/s1

InChI key: InChIKey=HCAJQHYUCKICQH-VPENINKCSA-N

SMILES: O=C1N(C2=C(N1)C(=O)N=C(N)N2)[C@@H]3O[C@H](CO)[C@@H](O)C3

Synonyms:

• 2'-Deoxy-8-Oxoguanosine
• 2′-Deoxy-7,8-dihydro-8-oxoguanosine
• 7,8-Dihydro-2'-deoxy-8-oxoguanosine
• 7,8-Dihydro-8-oxo-2′-deoxyguanosine
• 7,8-Dihydro-8-oxodeoxyguanosine
• 8-Hydroxydeoxyguanosine
• 8-Oxo-2'-deoxyguanine
• 8-Oxo-2′-deoxyguanosine
• 8-Oxo-7,8-dihydro-2'-deoxyguanosine
• 8-Oxo-7,8-dihydrodeoxyguanosine
• 8-Oxo-7-hydrodeoxyguanosine
• 8-Oxo-dG
• 8-Oxodeoxyguanosine
• Ccris 8239
• Guanosine, 2'-deoxy-7,8-dihydro-8-oxo-
• Guanosine, 7,8-dihydro-2'-deoxy-8-oxo-
• 8-Hydroxy-2'-deoxyguanosine

8-OXO-2'-DEOXYGUANOSINE

CAS: 88847-89-6

Formula: C₁₀H₁₃N₅O₅

Purity: 95%

Color and Shape: Solid

Molecular weight: 283.2407

Ref: IN-DA003GJ0

8-Hydroxy-2'-deoxyguanosine

CAS: 88847-89-6

8-Hydroxy-2'-deoxyguanosine

Purity: ≥95%

Molecular weight: 283.24g/mol

Ref: 54-BUP04565

8-Hydroxy-2'-deoxyguanosine

CAS: 88847-89-6

8-Hydroxy-2'-deoxyguanosine

Purity: 95%

Molecular weight: 283.24g/mol

Ref: 54-OR1010294

2''-Deoxy-8-oxoguanosine

CAS: 88847-89-6

Formula: C₁₀H₁₃N₅O₅

Purity: ≥ 95.0%

Color and Shape: White to off-white powder or crystalline powder

Molecular weight: 283.24

Ref: 7W-GN0582

8-Hydroxy-2'-Deoxyguanosine

CAS: 88847-89-6

Formula: C₁₀H₁₃N₅O₅

Molecular weight: 283.24

Ref: 4Z-G-2432

8-Hydroxy-2'-deoxyguanosine

CAS: 88847-89-6

8-Hydroxy-2'-deoxyguanosine (8-OHdG) is a good biomarker for risk assessment of various cancers and degenerative diseases.

Formula: C₁₀H₁₃N₅O₅

Purity: 99.10%

Color and Shape: White Solid

Molecular weight: 283.24

Ref: TM-T8343

8-Oxo-2’-deoxyguanosine-13C,15N2

Controlled Product

CAS: 88847-89-6

Applications A marker compound indicative of DNA damage associated with mutagenesis and carcinogenesis. Can induce differentiation of Friend murine erythroleukemia cells in vitro.
References Ueda, T., et al.: Chem. Pharm. Bull., 26, 2122 (1978), Jiang, F., et al.: Nature, 183, 382 (1996),

Formula: C₉₁₃CH₁₃N₃₁₅N₂O₅

Color and Shape: Neat

Molecular weight: 286.22

Ref: TR-O850252

8-Oxo-2’-deoxyguanosine

Controlled Product

CAS: 88847-89-6

Applications A marker compound indicative of DNA damage associated with mutagenesis and carcinogenesis. Can induce differentiation of Friend murine erythroleukemia cells in vitro.
References Ueda, T., et al.: Chem. Pharm. Bull., 26, 2122 (1978), Jiang, F., et al.: Nature, 183, 382 (1996),

Formula: C₁₀H₁₃N₅O₅

Color and Shape: White To Beige

Molecular weight: 283.24

Ref: TR-O850250

8-Hydroxy-2′-deoxyguanosine

CAS: 88847-89-6

Formula: C₁₀H₁₃N₅O₅

Molecular weight: 283.24

Ref: ST-EA-CP-A88043

2'-Deoxy-8-oxoguanosine

CAS: 88847-89-6

2'-Deoxy-8-oxoguanosine (8-OHdG) is a product of oxidative DNA damage. The presence of 8-OHdG in urine has been used to detect and measure the degree of oxidative DNA damage in humans and animals, which may be linked to cancer and aging. When 8-OHdG is excreted into urine, it can react with other molecules such as protein or inorganic phosphorus, causing more oxidative DNA damage. 2'-Deoxy-8-oxoguanosine has also been shown to cause cell toxicity by damaging the cell's squamous epithelium, leading to cancer.For the 15N5 labelled version please check ND09970.

Formula: C₁₀H₁₃N₅O₅

Purity: Min. 95 Area-%

Color and Shape: White Powder

Molecular weight: 283.25 g/mol

Ref: 3D-ND06344

2-Amino-9-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-3H-purine-6,8(7H,9H)-dione

CAS: 88847-89-6

Formula: C₁₀H₁₃N₅O₅

Purity: 95%

Color and Shape: Solid

Molecular weight: 283.244

Ref: 10-F460639