CAS 88859-04-5

Mafosfamide

Description:

Mafosfamide is a chemotherapeutic agent primarily used in the treatment of certain types of cancers, particularly in pediatric oncology. It is a prodrug of the alkylating agent ifosfamide, which means it is converted into its active form in the body. Mafosfamide is characterized by its ability to form DNA cross-links, thereby inhibiting DNA synthesis and function, which ultimately leads to cell death, particularly in rapidly dividing cancer cells. The compound is typically administered intravenously and is known for its potential side effects, which can include myelosuppression, gastrointestinal disturbances, and neurotoxicity. Its chemical structure includes a phosphoramide moiety, which contributes to its mechanism of action. Due to its specific targeting of cancer cells, mafosfamide is often used in combination with other chemotherapeutic agents to enhance therapeutic efficacy. As with many chemotherapeutics, careful monitoring of patients is essential to manage adverse effects and optimize treatment outcomes.

Formula: C₉H₁₉Cl₂N₂O₅PS₂

InChI: InChI=1/C9H19Cl2N2O5PS2/c10-2-4-13(5-3-11)19(14)12-9(1-6-18-19)20-7-8-21(15,16)17/h9H,1-8H2,(H,12,14)(H,15,16,17)/t9-,19-/s2

InChI key: InChIKey=PBUUPFTVAPUWDE-QDKBNZBTNA-N

SMILES: N(CCCl)(CCCl)P1(=O)N[C@H](SCCS(=O)(=O)O)CCO1

Synonyms:

• (+-)-2-((2-(Bis(2-chloroethyl)amino)tetrahydro-2H-1,3,2-oxazaphosphorin-4-yl)thio)ethanesulfonic acid P-cis-oxide
• 2-({2-[Bis(2-Chloroethyl)Amino]-2-Oxido-1,3,2-Oxazaphosphinan-4-Yl}Sulfanyl)Ethanesulfonic Acid
• 2H-1,3,2-Oxazaphosphorine, ethanesulfonic acid deriv.
• Ethanesulfonic acid, 2-(((2R,4R)-2-(bis(2-chloroethyl)amino)tetrahydro-2H-1,3,2-oxazaphosphorin-4-yl)thio)-, rel-
• Ethanesulfonic acid, 2-((2-(bis(2-chloroethyl)amino)tetrahydro-2H-1,3,2-oxazaphosphorin-4-yl)thio)-, P-oxide, cis-(+-)-
• Ethanesulfonic acid, 2-[[(2R,4R)-2-[bis(2-chloroethyl)amino]tetrahydro-2-oxido-2H-1,3,2-oxazaphosphorin-4-yl]thio]-, rel-
• Ethanesulfonic acid, 2-[[2-[bis(2-chloroethyl)amino]tetrahydro-2-oxido-2H-1,3,2-oxazaphosphorin-4-yl]thio]-, cis-
• Mafosfamid
• Mafosfamida
• Mafosfamida [Spanish]
• Mafosfamide [INN]
• Mafosfamidum
• Mafosfamidum [Latin]
• Unii-5970Hh9923
• Z 7557
• cis-Mafosfamide
• rel-2-[[(2R,4R)-2-[Bis(2-chloroethyl)amino]tetrahydro-2-oxido-2H-1,3,2-oxazaphosphorin-4-yl]thio]ethanesulfonic acid

Mafosfamide

CAS: 88859-04-5

Mafosfamide, a synthetic oxazaphosphorine, alkylates DNA to prevent synthesis and treat neoplastic meningitis without hepatic activation.

Formula: C₉H₁₉Cl₂N₂O₅PS₂

Color and Shape: Solid

Molecular weight: 401.27

Ref: TM-T68434