CAS 88899-55-2

Bafilomycin A1

Description:

Bafilomycin A1 is a macrolide antibiotic that is primarily known for its role as a potent inhibitor of vacuolar-type H+-ATPases (V-ATPases), which are essential for acidifying intracellular compartments in eukaryotic cells. This compound is derived from the fermentation of the bacterium Streptomyces griseus and exhibits a complex structure characterized by a large lactone ring and multiple functional groups, contributing to its biological activity. Bafilomycin A1 is often utilized in research to study cellular processes such as autophagy, endocytosis, and lysosomal function due to its ability to disrupt proton gradients across membranes. Additionally, it has been investigated for its potential therapeutic applications in cancer and other diseases where V-ATPase activity is implicated. The substance is typically handled with care in laboratory settings due to its bioactive nature and potential cytotoxic effects. Its solubility properties and stability can vary depending on the solvent and environmental conditions, making it important to consider these factors during experimental applications.

Formula: C₃₅H₅₈O₉

InChI: InChI=1/C35H58O9/c1-19(2)32-24(7)27(36)18-35(40,44-32)26(9)31(38)25(8)33-28(41-10)14-12-13-20(3)15-22(5)30(37)23(6)16-21(4)17-29(42-11)34(39)43-33/h12-14,16-17,19,22-28,30-33,36-38,40H,15,18H2,1-11H3/b14-12+,20-13+,21-16+,29-17-/t22-,23+,24-,25-,26-,27+,28-,30-,31+,32+,33+,35+/m0/s1

InChI key: InChIKey=XDHNQDDQEHDUTM-JQWOJBOSSA-N

SMILES: [C@@H]([C@@H]([C@H](C)[C@@]1([C@@H](OC)/C=C/C=C(\C)/C[C@H](C)[C@H](O)[C@H](C)/C=C(\C)/C=C(\OC)/C(=O)O1)[H])O)(C)[C@]2(O)O[C@H](C(C)C)[C@@H](C)[C@H](O)C2

Synonyms:

• (-)-Bafilomycin A₁
• (3Z,5E,7R,8S,9S,11E,13E,15S,16R)-8-Hydroxy-16-[(1S,2R,3S)-2-hydroxy-1-methyl-3-[(2R,4R,5S,6R)-tetrahydro-2,4-dihydroxy-5-methyl-6-(1-methylethyl)-2H-pyran-2-yl]butyl]-3,15-dimethoxy-5,7,9,11-tetramethyloxacyclohexadeca-3,5,11,13-tetraen-2-one
• (5R)-2,4-Dideoxy-1-C-{(2S,3R,4S)-3-hydroxy-4-[(2R,3S,4E,6E,9S,10S,11R,12E,14Z)-10-hydroxy-3,15-dimethoxy-7,9,11,13-tetramethyl-16-oxooxacyclohexadeca-4,6,12,14-tetraen-2-yl]pentan-2-yl}-5-isopropyl-4-methyl-alpha-D-threo-pentopyranose
• Hygrolidin, 21-O-de(3-carboxy-1-oxo-2-propenyl)-2-demethyl-2-methoxy-24-methyl-
• NSC 381866
• Oxacyclohexadeca-3,5,11,13-tetraen-2-one, 8-hydroxy-16-[(1S,2R,3S)-2-hydroxy-1-methyl-3-[(2R,4R,5S,6R)-tetrahydro-2,4-dihydroxy-5-methyl-6-(1-methylethyl)-2H-pyran-2-yl]butyl]-3,15-dimethoxy-5,7,9,11-
• Oxacyclohexadeca-3,5,11,13-tetraen-2-one, 8-hydroxy-16-[(1S,2R,3S)-2-hydroxy-1-methyl-3-[(2R,4R,5S,6R)-tetrahydro-2,4-dihydroxy-5-methyl-6-(1-methylethyl)-2H-pyran-2-yl]butyl]-3,15-dimethoxy-5,7,9,11-tetramethyl-, (3Z,5E,7R,8S,9S,11E,13E,15S,16R)-
• Oxacyclohexadeca-3,5,11,13-tetraen-2-one, 8-hydroxy-16-[2-hydroxy-1-methyl-3-[tetrahydro-2,4-dihydroxy-5-methyl-6-(1-methylethyl)-2H-pyran-2-yl]butyl]-3,15-dimethoxy-5,7,9,11-tetramethyl-, [7R-[3Z,5E,7R*,8S*,9S*,11E,13E,15S*,16R*[1S*,2R*,3S*(2R*,4R*,5S*,6R*)]]]-
• Oxacyclohexadecane, hygrolidin deriv.
• alpha-D-threo-Pentopyranose, 2,4-dideoxy-1-C-[(1S,2R,3S)-2-hydroxy-3-[(2R,3S,4E,6E,9S,10S,11R,12E,14Z)-10-hydroxy-3,15-dimethoxy-7,9,11,13-tetramethyl-16-oxooxacyclohexadeca-4,6,12,14-tetraen-2-yl]-1-methylbutyl]-4-methyl-5-C-(1-methylethyl)-, (5R)-
• tetramethyl-, (3Z,5E,7R,8S,9S,11E,13E,15S,16R)-
• (5R)-2,4-Dideoxy-1-C-{(2S,3R,4S)-3-hydroxy-4-[(2R,3S,4E,6E,9R,10S,11R,12E,14Z)-10-hydroxy-3,15-dimethoxy-7,9,11,13-tetramethyl-16-oxooxacyclohexadeca-4,6,12,14-tetraen-2-yl]-2-pentanyl}-5-isopropyl-4-methyl-alpha-D-threo-pentopyranose
• alpha-D-threo-pentopyranose, 2,4-dideoxy-1-C-[(1S,2R,3S)-2-hydroxy-3-[(2R,3S,4E,6E,9R,10S,11R,12E,14Z)-10-hydroxy-3,15-dimethoxy-7,9,11,13-tetramethyl-16-oxooxacyclohexadeca-4,6,12,14-tetraen-2-yl]-1-methylbutyl]-4-methyl-5-C-(1-methylethyl)-, (5R)-
• Bafilomycin A1
• (5R)-2,4-Dideoxy-1-C-{(2S,3R,4S)-3-hydroxy-4-[(2R,3S,4E,6E,9R,10S,11R,12E,14Z)-10-hydroxy-3,15-dimethoxy-7,9,11,13-tetramethyl-16-oxooxacyclohexadeca-4,6,12,14-tetraen-2-yl]pentan-2-yl}-5-isopropyl-4-methyl-alpha-D-threo-pentopyranose
• (3Z,5E,7R,8S,9S,11E,13E,15S,16R)-8-Hydroxy-16-((1S,2R,3S)-2-hydroxy-1-methyl-3-((2R,4R,5S,6R)-tetrahydro-2,4-dihydroxy-5
• Bafilomycin A1 Bafilomycin A1 from Streptomyces griseus
• Bafilomycin A1 from Streptomycesgriseus, 10 ug
• BAFILOMYCIN A1, STREPTOMYCES GRISEUS
• (3Z,5E,7R,8S,9S,11E,13E,15S,16R)-8-Hydroxy-16-[(1S,2R,3S)-2-hydroxy-1-Methyl-3-[(2R,4R,5S,6R)-tetrahydro-2,4-dihydroxy-5-Methyl-6-(1-Methylethyl)-2H-pyran-2-yl]butyl]-3,15-diMethoxy-5,7,9,11-tetraMethyloxacyclohexadeca-3,5,11,13-tetraen-2-o
• BAFILOMYCIN A1, 98+%
• BafilomycinA1fromStreptomycesgriseus
• 21-O-de(3-carboxy-1-oxo-2-propenyl)-2-demethyl-2-methoxy-24-methyl-hygrolidin
• BAFILOMYCIN A1 95%
• Bafilomycin A1(Baf-A1)

Bafilomycin A1

CAS: 88899-55-2

Bafilomycin A1, 88899-55-2, is a specific inhibitor of vacuolar ATPases which exhibits antibacterial, antifungal, antineoplastic, and immunosuppressive properties. Learn more.

Formula: C₃₅H₅₈O₉

Color and Shape: White, Solid or film

Molecular weight: 622.84

Ref: 02-J61835

Bafilomycin A1, 0.1 mg/ml in DMSO, sterile-filtered

CAS: 88899-55-2

Bafilomycin A1, 88899-55-2, is a specific inhibitor of vacuolar ATPases which exhibits antibacterial, antifungal, antineoplastic, and immunosuppressive properties. Learn more.

Formula: C₃₅H₅₈O₉

Color and Shape: Liquid, Pale yellow

Molecular weight: 622.84

Ref: 02-J67193

(3Z,5E,7R,8S,9S,11E,13E,15S,16R)-8-Hydroxy-16-[(1S,2R,3S)-2-hydroxy-1-methyl-3-[(2R,4R,5S,6R)-tetrahydro-2,4-dihydroxy-5-methyl-6-(1-methylethyl)-2H-pyran-2-yl]butyl]-3,15-dimethoxy-5,7,9,11-tetramethyloxacyclohexadeca-3,5,11,13-tetraen-2-one

CAS: 88899-55-2

Formula: C₃₅H₅₈O₉

Purity: %

Color and Shape: Solid

Molecular weight: 622.8296

Ref: IN-DA0039AQ

Bafilomycin A1

CAS: 88899-55-2

Bafilomycin A1

Purity: ≥95%

Molecular weight: 622.83g/mol

Ref: 54-BUP16335

Bafilomycin A1

CAS: 88899-55-2

Bafilomycin A1

Formula: C₃₅H₅₈O₉

Purity: By hplc: >95% (Typical Value in Batch COA)

Color and Shape: white lyophilizate solid

Molecular weight: 622.83g/mol

Ref: 54-BIB0132

Bafilomycin A1

CAS: 88899-55-2

Bafilomycin A1 belongs to the macrolide class of antibiotics and is a V-ATPase (IC50=0.44 nM) that is specific and reversible.

Formula: C₃₅H₅₈O₉

Purity: 95.87% - 99.36%

Color and Shape: Solid

Molecular weight: 622.83

Ref: TM-T6740

Bafilomycin A1

CAS: 88899-55-2

Formula: C₃₅H₅₈O₉

Purity: ≥ 97.0%

Color and Shape: White or off-white solid

Molecular weight: 622.83

Ref: 7W-GA6363

Bafilomycin A1

Controlled Product

CAS: 88899-55-2

Stability Hygroscopic
Applications Bafilomycin A1 is a specific inhibitor of vacuolar type H+-ATPase (V-ATPase) in animal cells, plant cells and microorganisms.
References Bownman, E., et al.: PNAS, 85, 7972 (1988); Umata, T., et al.: J. Biol. Chem., 265, 21940 (1990); Saurin, A., et al.: Biochem.

Formula: C₃₅H₅₈O₉

Color and Shape: Neat

Molecular weight: 622.83

Ref: TR-B110000

Bafilomycin A1

CAS: 88899-55-2

Inhibitor of vacuolar-type proton pump

Formula: C₃₅H₅₈O₉

Purity: Min. 95 Area-%

Color and Shape: White Powder

Molecular weight: 622.83 g/mol

Ref: 3D-FB146475