CAS 88899-56-3

Bafilomycin B1

Description:

Bafilomycin B1 is a macrolide antibiotic that is primarily known for its role as a potent inhibitor of vacuolar-type H+-ATPases (V-ATPases). This compound is derived from the fermentation of the bacterium Streptomyces griseus and exhibits significant biological activity, particularly in the modulation of intracellular pH and membrane trafficking processes. Bafilomycin B1 is characterized by its ability to disrupt proton gradients across membranes, which is crucial for various cellular functions, including endocytosis and autophagy. The compound is often utilized in research settings to study cellular processes and the role of V-ATPases in health and disease. In terms of physical properties, Bafilomycin B1 is typically a white to off-white solid, soluble in organic solvents, and has a complex molecular structure that contributes to its biological activity. Due to its specific mechanism of action, it has potential applications in cancer research and the study of neurodegenerative diseases. However, its use is primarily confined to laboratory settings due to its potent effects on cellular physiology.

Formula: C₄₄H₆₅NO₁₃

InChI: InChI=1S/C44H65NO13/c1-23(2)41-28(7)35(56-37(49)18-17-36(48)45-38-31(46)15-16-32(38)47)22-44(53,58-41)30(9)40(51)29(8)42-33(54-10)14-12-13-24(3)19-26(5)39(50)27(6)20-25(4)21-34(55-11)43(52)57-42/h12-14,17-18,20-21,23,26-30,33,35,39-42,46,50-51,53H,15-16,19,22H2,1-11H3,(H,45,48)/b14-12+,18-17+,24-13+,25-20+,34-21-/t26-,27+,28-,29-,30-,33-,35+,39-,40+,41+,42+,44+/m0/s1

InChI key: InChIKey=KFUFLYSBMNNJTF-ANDWMEETSA-N

SMILES: [C@@H]([C@@H]([C@H](C)[C@@]1([C@@H](OC)/C=C/C=C(\C)/C[C@H](C)[C@H](O)[C@H](C)/C=C(\C)/C=C(\OC)/C(=O)O1)[H])O)(C)[C@@]2(O)C[C@@H](OC(/C=C/C(NC=3C(=O)CCC3O)=O)=O)[C@H](C)[C@@H]([C@@H](C)C)O2

Synonyms:

• 2-Butenoic acid, 4-[(2-hydroxy-5-oxo-1-cyclopenten-1-yl)amino]-4-oxo-, (2R,4R,5S,6R)-tetrahydro-2-hydroxy-2-[(1S,2R,3S)-2-hydroxy-3-[(2R,3S,4E,6E,9S,10S,11R,12E,14Z)-10-hydroxy-3,15-dimethoxy-7,9,11,13-tetramethyl-16-oxooxacyclohexadeca-4,6,12,14-tetraen-2-yl]-1-methylbutyl]-5-methyl-6-(1-methylethyl)-2H-pyran-4-yl ester, (2E)-
• Hygrolidin, 37-decarboxy-2-demethyl-37-[[(2-hydroxy-5-oxo-1-cyclopenten-1-yl)amino]carbonyl]-2-methoxy-24-methyl-
• Setamycin
• Bafilomycin B1
• Oxacyclohexadecane, hygrolidin deriv.

Bafilomycin B1

CAS: 88899-56-3

Bafilomycin B1

Formula: C₄₃H₆₃NO₁₃

Purity: By hplc: 98.17% (Typical Value in Batch COA)

Color and Shape: yellow powder

Molecular weight: 801.95922g/mol

Ref: 54-BIBR1013

Bafilomycin B1

CAS: 88899-56-3

Bafilomycin B1, a Streptomyces-derived macrolide, inhibits E. coli ATPase and fights Gram-positive bacteria and fungi.

Formula: C₄₄H₆₅NO₁₃

Purity: 98%

Color and Shape: White Powder

Molecular weight: 815.998

Ref: TM-T10455

Bafilomycin B1

CAS: 88899-56-3

Formula: C₄₄H₆₅NO₁₃

Molecular weight: 815.99

Ref: 7W-GA8347

Bafilomycin B1

Controlled Product

CAS: 88899-56-3

Stability Hygroscopic
Applications Bafilomycin B1 is an inhibitor of vacuolar-ATPase enzymes in fungi.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Formula: C₄₄H₆₅NO₁₃

Color and Shape: Neat

Molecular weight: 815.99

Ref: TR-B110005

Bafilomycin B1

CAS: 88899-56-3

Bafilomycin B1 is an antibiotic belonging to the plecomacrolide class, which is derived from the bacterium Streptomyces. This compound acts as a potent inhibitor of vacuolar H+-ATPases (V-ATPases), enzymes responsible for acidifying intracellular compartments in eukaryotic cells. By selectively binding to the V0 sector of these ATPases, Bafilomycin B1 disrupts proton translocation across cellular membranes, effectively halting the acidification process.

Formula: C₄₄H₆₅NO₁₃

Purity: Min. 95%

Molecular weight: 815.99 g/mol

Ref: 3D-NDA89956