CAS 88937-61-5

Z-Arg-Arg-AMC

Description:

Z-Arg-Arg-AMC, also known by its CAS number 88937-61-5, is a synthetic peptide substrate commonly used in biochemical research, particularly in studies involving proteases and enzyme activity. This compound features a Z (benzyloxycarbonyl) protecting group on the N-terminal arginine residue, which enhances its stability and solubility. The presence of two arginine residues in its structure makes it a substrate for various enzymes, particularly those that cleave at basic amino acids. The AMC (7-amino-4-methylcoumarin) moiety serves as a fluorescent reporter, allowing for the quantification of enzymatic activity through fluorescence measurements. Z-Arg-Arg-AMC is often utilized in assays to study proteolytic activity, providing insights into enzyme kinetics and substrate specificity. Its characteristics include high solubility in aqueous solutions, stability under physiological conditions, and the ability to produce a measurable fluorescent signal upon cleavage, making it a valuable tool in molecular biology and biochemistry research.

Formula: C₃₀H₃₉N₉O₆

InChI: InChI=1/C30H39N9O6/c1-18-15-25(40)45-24-16-20(11-12-21(18)24)37-22(9-5-13-35-28(31)32)26(41)39-27(42)23(10-6-14-36-29(33)34)38-30(43)44-17-19-7-3-2-4-8-19/h2-4,7-8,11-12,15-16,22-23,37H,5-6,9-10,13-14,17H2,1H3,(H,38,43)(H4,31,32,35)(H4,33,34,36)(H,39,41,42)/t22-,23-/m0/s1

InChI key: InChIKey=DLELKZFCVLJXKZ-GOTSBHOMSA-N

SMILES: CC=1C=2C(=CC(NC([C@@H](NC([C@@H](NC(OCC3=CC=CC=C3)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)=CC2)OC(=O)C1

Synonyms:

• Z-Arg-Arg-AMC
• Benzyloxycarbonyl-L-arginyl-L-arginine 4-methylcoumaryl-7-amide
• 386: PN: US20220178935 SEQID: 1064 claimed sequence
• N2-[(Phenylmethoxy)carbonyl]-L-arginyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-L-argininamide
• L-Argininamide, N2-[(phenylmethoxy)carbonyl]-L-arginyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-
• Z-Arg-Arg-NHMec
• Z-ARG-ARG-MCA(HYDROCHLORIDE FORM)
• Z-ARG-ARG-MCA HYDROCHLORIDE
• BENZYLOXYCARBONYL-L-ARGINYL-L-ARGININE 4-METHYLCOUMARYL-7-AMIDE HYDROCHLORIDE
• benzyl N-[(2S)-5-(diaminomethylideneamino)-1-[[(2S)-5-(diaminomethylideneamino)-2-[(4-methyl-2-oxochromen-7-yl)amino]pentanoyl]amino]-1-oxopentan-2-yl]carbamate
• N-ALPHA-CBZ-ARG-ARG 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE
• Z-ARG-ARG-AMC HYDROCHLORIDE SALT
• benzyloxycarbonylarginyl-arginine 4-methylcoumarin-7-ylamide

Z-Arg-Arg-AMC

CAS: 88937-61-5

Z-RR-AMC, an excellent, specific substrate for cathepsin B, an enzyme found in secretory vesicles. Cathepsin B has been identified as a β-secretase, as such it is involved in β-amyloid production. Z-RR-AMC is a convenient fluorogenic substrate for stem bromelain, as it is scarcely affected by fruit bromelain.

Formula: C₃₀H₃₉N₉O₆

Purity: > 98%

Color and Shape: White Powder

Molecular weight: 621.7

Ref: 01-4004789

Z-Arg-Arg-AMC hydrochloride salt

CAS: 88937-61-5

Z-Arg-Arg-AMC hydrochloride salt is a versatile compound that acts as a catalyst and forms strong hydrogen bonds. It exhibits proteolytic activity and has been found to be effective in breaking down proteins. In addition, Z-Arg-Arg-AMC hydrochloride salt has been shown to possess neuroprotective properties, making it a potential candidate for the treatment of neurological disorders. It also demonstrates anthelmintic activity, which means it can be used to combat parasitic worm infections. Furthermore, this compound has antioxidant activity and can help reduce lipid peroxidation, protecting cells from oxidative damage. With its diverse range of characteristics, Z-Arg-Arg-AMC hydrochloride salt holds great promise in various research fields such as biochemistry and medicine.

Formula: C₃₀H₃₉N₉O₆·xHCl

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 621.69 g/mol

Ref: 3D-FA110491

Z-Arg-Arg-AMC

CAS: 88937-61-5

Z-Arg-Arg-AMC is an activator of the receptor tyrosine kinase (RTK) system. It binds to the extracellular domain of RTKs, such as epidermal growth factor receptors (EGFR) and fibroblast growth factor receptors (FGFR), and activates these receptors. This compound has been shown to activate EGFR and FGFR at low concentrations and inhibit their activation at high concentrations. Z-Arg-Arg-AMC has also been shown to be a potent inhibitor of protein interactions with a Kd of approximately 1 μM, which makes it a useful research tool for studying protein interactions.

Formula: C₃₀H₃₉N₉O₆

Purity: Min. 95%

Molecular weight: 621.69 g/mol

Ref: 3D-MRR-3123-V