CAS 89-24-7

Phenylhydantoin

Description:

Phenylhydantoin, also known as phenytoin, is an anticonvulsant medication primarily used to manage seizures, particularly in epilepsy. It is classified as a hydantoin derivative and has a chemical formula of C15H15N2O2. This substance appears as a white to off-white crystalline powder and is relatively insoluble in water but soluble in organic solvents like ethanol and acetone. Phenylhydantoin functions by stabilizing neuronal membranes and reducing the excitability of neurons, thereby preventing seizure activity. Its mechanism of action involves the modulation of sodium channels, which helps to maintain the balance of electrical activity in the brain. The compound is typically administered orally or intravenously, and its pharmacokinetics can be influenced by factors such as dosage, formulation, and individual patient metabolism. Side effects may include dizziness, drowsiness, and potential long-term effects on bone health. Due to its narrow therapeutic index, careful monitoring of blood levels is essential to avoid toxicity and ensure effective treatment.

Formula: C₉H₈N₂O₂

InChI: InChI=1S/C9H8N2O2/c12-8-7(10-9(13)11-8)6-4-2-1-3-5-6/h1-5,7H,(H2,10,11,12,13)

InChI key: InChIKey=NXQJDVBMMRCKQG-UHFFFAOYSA-N

SMILES: O=C1C(NC(=O)N1)C2=CC=CC=C2

Synonyms:

• 2,4-Imidazolidinedione, 5-phenyl-
• 5-Phenyl-2,4-imidazolidinedione
• 5-Phenylimidazolidine-2,4-Dione
• 5-Phenylimidazoline-2,4-dione
• <span class="text-smallcaps">DL</span>-5-Phenylhydantoin
• Ai3-61187
• Hydantoin, 5-phenyl-
• Hydantoin, 5-phenyl- (8CI)
• NSC 40885
• NSC 51847
• Nsc 27302
• Phenylhydantoin

5-Phenylhydantoin

CAS: 89-24-7

Formula: C₉H₈N₂O₂

Purity: >99.0%(T)(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 176.18

Ref: 3B-P0666

5-Phenylhydantoin

CAS: 89-24-7

Hydantoin and its derivatives

Formula: C₉H₈N₂O₂

Color and Shape: Powder

Molecular weight: 176.05858

Ref: 45-1533308

Phenylhydantoin

CAS: 89-24-7

5-Phenylhydantoin is a Mephenytoin metabolite with anti-epileptic effects, targeting NVSCs.

Formula: C₉H₈N₂O₂

Purity: 98.09% - 98.91%

Color and Shape: White Solid

Molecular weight: 176.17

Ref: TM-T0596

5-Phenylimidazolidine-2,4-dione

CAS: 89-24-7

Formula: C₉H₈N₂O₂

Purity: 95%

Color and Shape: Solid

Molecular weight: 176.1720

Ref: IN-DA004265

Phenylhydantoin

CAS: 89-24-7

Phenylhydantoin

Purity: ≥98%

Molecular weight: 176.17g/mol

Ref: 54-BUP17843

5-Phenylhydantoin

CAS: 89-24-7

5-Phenylhydantoin

Purity: 95%

Molecular weight: 176.17g/mol

Ref: 54-OR924678

5-Phenylimidazolidine-2,4-dione

CAS: 89-24-7

Formula: C₉H₈N₂O₂

Purity: 95%

Color and Shape: Solid, White to almost white powder

Molecular weight: 176.175

Ref: 10-F068693

5-Phenylhydantoin

Controlled Product

CAS: 89-24-7

Applications A metabolite of Mephenytoin. This molecule has been shown to bind to voltage-dependent sodium channels (NVSC) and has antiepileptic properties.
References Maguire, J., et al.: Eur. J. Pharmacol. 117, 135 (1985), Brown, M.L., et al.: J. Med. Chem., 40, 602 (1997),

Formula: C₉H₈N₂O₂

Color and Shape: Neat

Molecular weight: 176.17

Ref: TR-P335000