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CAS 89139-42-4

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Teicoplanin aglycon

Description:
Teicoplanin aglycon is a glycopeptide antibiotic derived from the fermentation of the bacterium *Amycolatopsis orientalis*. It is primarily used for its antibacterial properties, particularly against Gram-positive bacteria, including methicillin-resistant *Staphylococcus aureus* (MRSA). The compound exhibits a complex structure characterized by a core heptapeptide backbone, which is crucial for its mechanism of action, primarily inhibiting bacterial cell wall synthesis by binding to the D-alanyl-D-alanine terminus of peptidoglycan precursors. Teicoplanin aglycon is less soluble than its glycosylated forms, which can affect its pharmacokinetics and bioavailability. It is typically administered parenterally and has a long half-life, allowing for less frequent dosing. The substance is also known for its low toxicity profile, making it a preferred choice in treating serious infections. However, resistance can develop, necessitating careful monitoring of its use in clinical settings. Overall, Teicoplanin aglycon plays a significant role in the treatment of severe bacterial infections, particularly in patients with compromised immune systems.
Formula:C58H45Cl2N7O18
InChI:InChI=1S/C58H45Cl2N7O18/c59-32-9-21-1-7-38(32)84-41-16-26-17-42(51(41)74)85-39-8-4-24(14-33(39)60)50(73)49-57(80)66-48(58(81)82)31-19-28(69)20-37(72)43(31)30-13-23(3-5-35(30)70)45(54(77)67-49)64-56(79)47(26)65-55(78)46-25-11-27(68)18-29(12-25)83-40-15-22(2-6-36(40)71)44(61)53(76)62-34(10-21)52(75)63-46/h1-9,11-20,34,44-50,68-74H,10,61H2,(H,62,76)(H,63,75)(H,64,79)(H,65,78)(H,66,80)(H,67,77)(H,81,82)/t34-,44-,45-,46+,47-,48+,49+,50-/m1/s1
InChI key:InChIKey=DKVBOUDTNWVDEP-NJCHZNEYSA-N
SMILES:OC1=C2C([C@@H](C(O)=O)NC(=O)[C@@]3([C@H](O)C=4C=C(Cl)C(=CC4)OC=5C=C6[C@](C(=O)N[C@](C=7C=C2C(O)=CC7)(C(=O)N3)[H])(NC(=O)[C@@]8(C=9C=C(OC=%10C=C([C@@H](N)C(=O)N[C@@](C(=O)N8)(CC=%11C=C(Cl)C(OC(=C6)C5O)=CC%11)[H])C=CC%10O)C=C(O)C9)[H])[H])[H])=CC(O)=C1
Synonyms:
  • Aglucoteicoplanin
  • Teicoplanin aglycon
  • Antibiotic A 41030B
  • Antibiotic L 17392
  • Teicoplanin aglycone
  • Teicoplanin aglycone
  • Ristomycin A aglycone, 22,31-dichloro-7-demethyl-64-O-demethyl-19-deoxy-
  • 1H,15H,34H-20,23:30,33-Dietheno-3,18:35,48-bis(iminomethano)-4,8:10,14:25,28:43,47-tetrametheno-28H-[1,14,6,22]dioxadiazacyclooctacosino[4,5-m][10,2,16]benzoxadiazacyclotetracosine, ristomycin A aglycone deriv.
  • TD-A 3
  • 22,31-Dichloro-7-demethyl-64-O-demethyl-19-deoxyristomycin A aglycone
  • See more synonyms
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Found 1 products.
  • Teicoplanin aglycone
    Targetmol
    + Info

    Teicoplanin aglycone

    CAS:
    <p>Teicoplanin aglycone: Glycopeptide antibiotic for serious Gram-positive infections including MRSA and E. faecalis.</p>
    Formula:C58H45Cl2N7O18
    Purity:98%
    Color and Shape:Solid
    Molecular weight:1198.93

    Ref: TM-T26256