CAS 89226-50-6

Manidipine

Description:

Manidipine is a calcium channel blocker primarily used in the treatment of hypertension and certain cardiovascular conditions. It belongs to the dihydropyridine class of calcium antagonists, which work by inhibiting the influx of calcium ions into vascular smooth muscle and cardiac cells, leading to vasodilation and reduced blood pressure. Manidipine is characterized by its high selectivity for vascular calcium channels, which minimizes effects on cardiac contractility. The substance is typically administered orally and has a relatively long half-life, allowing for once-daily dosing. Its chemical structure includes a dihydropyridine ring, which is essential for its pharmacological activity. Manidipine is known for its favorable side effect profile, with a lower incidence of reflex tachycardia compared to some other calcium channel blockers. Additionally, it may have beneficial effects on renal function, making it a suitable option for patients with hypertension and renal impairment. As with any medication, it is important to consider potential interactions and contraindications when prescribing Manidipine.

Formula: C₃₅H₃₈N₄O₆

InChI: InChI=1S/C35H38N4O6/c1-24-30(34(40)44-3)32(28-15-10-16-29(23-28)39(42)43)31(25(2)36-24)35(41)45-22-21-37-17-19-38(20-18-37)33(26-11-6-4-7-12-26)27-13-8-5-9-14-27/h4-16,23,32-33,36H,17-22H2,1-3H3

InChI key: InChIKey=ANEBWFXPVPTEET-UHFFFAOYSA-N

SMILES: C(OCCN1CCN(C(C2=CC=CC=C2)C3=CC=CC=C3)CC1)(=O)C=4C(C(C(OC)=O)=C(C)NC4C)C5=CC(N(=O)=O)=CC=C5

Synonyms:

• 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic Acid 2-[4-(Diphenylmethyl)-1-piperazinyl]ethyl Methyl Ester
• 2,6-Dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-[2-(4-benzhydryl-piperazin-1-yl)-ethyl] ester 5-methyl ester
• 2-(4-(Diphenylmethyl)-1-piperazinyl)ethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
• 2-[4-(Diphenylmethyl)-1-piperazinyl]ethylmethyl (±)-1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinecarboxylate
• 2-[4-(Diphenylmethyl)Piperazin-1-Yl]Ethyl Methyl 2,6-Dimethyl-4-(3-Nitrophenyl)-1,4-Dihydropyridine-3,5-Dicarboxylate
• 3,5-Pyridinedicarboxylic Acid, 1,4-Dihydro-2,6-Dimethyl-4-(3-Nitrophenyl)-, 2-[4-(Diphenylmethyl)-1-Piperazinyl]Ethyl Methyl Ester
• 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-[2-[4-(diphenylmethyl)-1-piperazinyl]ethyl] 5-methyl ester
• 5-({2-[4-(Diphenylmethyl)Piperazin-1-Yl]Ethoxy}Carbonyl)-1,2,6-Trimethyl-4-(3-Nitrophenyl)-1,4-Dihydropyridine-3-Carboxylate
• Franidipine
• Manidipine 6300
• Manidipine

Manidipine

CAS: 89226-50-6

Formula: C₃₅H₃₈N₄O₆

Color and Shape: Pale Yellow Solid

Molecular weight: 610.71

Ref: 4Z-M-265

3-(2-(4-Benzhydrylpiperazin-1-Yl)Ethyl) 5-Methyl 2,6-Dimethyl-4-(3-Nitrophenyl)-1,4-Dihydropyridine-3,5-Dicarboxylate

CAS: 89226-50-6

3-(2-(4-Benzhydrylpiperazin-1-Yl)Ethyl) 5-Methyl 2,6-Dimethyl-4-(3-Nitrophenyl)-1,4-Dihydropyridine-3,5-Dicarboxylate

Formula: C₃₅H₃₈N₄O₆

Purity: 99%

Molecular weight: 610.7

Ref: 54-OR1029539

Manidipine

CAS: 89226-50-6

Manidipine

Formula: C₃₅H₃₈N₄O₆

Purity: ≥98%

Molecular weight: 610.7

Ref: 54-BUP15661

Manidipine

CAS: 89226-50-6

Formula: C₃₅H₃₈N₄O₆

Purity: 99%

Color and Shape: Solid

Molecular weight: 610.6994

Ref: IN-DA000QAH

Manidipine

CAS: 89226-50-6

Manidipine (Iperten), a calcium channel blocker, which is dihydropyridine type. It is utilized

Formula: C₃₅H₃₈N₄O₆

Purity: 99.30%

Color and Shape: Solid

Molecular weight: 610.6994

Ref: TM-T6577

Manidipine

CAS: 89226-50-6

Formula: C₃₅H₃₈N₄O₆

Molecular weight: 610.7

Ref: BE-RMCM030000

Manidipine

Controlled Product

CAS: 89226-50-6

Applications A dihydropyridine calcium channel blocker. Antihypertensive.
References Meguro, K., et al.: Chem. Pharm. Bull., 33, 3787 (1985), Mizuno, K., et al.: Curr. Ther. Res., 52, 248 (1992)

Formula: C₃₅H₃₈N₄O₆

Color and Shape: Neat

Molecular weight: 610.7

Ref: TR-M164000