Cyclosporin A is a cyclic polypeptide composed of 11 amino acids, primarily known for its immunosuppressive properties. It is derived from the fungus Tolypocladium inflatum and is widely used in clinical settings to prevent organ transplant rejection and to treat autoimmune diseases. The structure of Cyclosporin A features a unique cyclic arrangement, which contributes to its ability to selectively inhibit T-cell activation by binding to cyclophilin, a cytosolic protein. This interaction disrupts the signaling pathways necessary for T-cell proliferation and cytokine production. The specific chemical structure includes a hydrophobic core, which enhances its membrane permeability, and various functional groups that contribute to its solubility and biological activity. Cyclosporin A is typically administered orally or intravenously and is known for its side effects, including nephrotoxicity and hypertension, necessitating careful monitoring of patients. Its pharmacokinetics can be influenced by factors such as liver metabolism and drug interactions, making individualized dosing essential for therapeutic efficacy.

Cyclosporin A, 3-(4-hydroxy-N-methyl-L-leucine)-6-[(2S,3R,4R,6E)-3-hydroxy-4-methyl-2-(methylamino)-6,8-nonadienoic acid]-

892495-53-3: Cyclosporin A is a cyclic polypeptide composed of 11 amino acids, primarily known for its immunosuppressive properties. It is derived from the fungus Tolypocladium inflatum and is widely used in clinical settings to prevent organ transplant rejection and to treat autoimmune diseases. The structure of Cyclosporin A features a unique cyclic arrangement, which contributes to its ability to selectively inhibit T-cell activation by binding to cyclophilin, a cytosolic protein. This interaction disrupts the signaling pathways necessary for T-cell proliferation and cytokine production. The specific chemical structure includes a hydrophobic core, which enhances its membrane permeability, and various functional groups that contribute to its solubility and biological activity. Cyclosporin A is typically administered orally or intravenously and is known for its side effects, including nephrotoxicity and hypertension, necessitating careful monitoring of patients. Its pharmacokinetics can be influenced by factors such as liver metabolism and drug interactions, making individualized dosing essential for therapeutic efficacy.

CAS 892495-53-3

Cyclosporin A, 3-(4-hydroxy-N-methyl-L-leucine)-6-[(2S,3R,4R,6E)-3-hydroxy-4-methyl-2-(methylamino)-6,8-nonadienoic acid]-

Voclosporin M4 (IM9) Metabolite

Ref: ST-EA-CP-V52002