CAS 89332-50-3
:Cilostazol
Description:
Cilostazol is a phosphodiesterase III inhibitor primarily used as a medication to treat intermittent claudication, a condition characterized by pain in the legs due to inadequate blood flow. It functions by promoting vasodilation and inhibiting platelet aggregation, thereby improving blood flow and reducing symptoms associated with peripheral artery disease. The chemical formula of cilostazol is C20H27N3O4S, and it features a thienopyridine structure, which is crucial for its pharmacological activity. Cilostazol is typically administered orally and is known for its relatively high bioavailability. It undergoes extensive hepatic metabolism, primarily via cytochrome P450 enzymes, leading to several metabolites, some of which may also exhibit pharmacological effects. Common side effects include headache, diarrhea, and palpitations. Due to its mechanism of action, cilostazol is contraindicated in patients with heart failure and should be used cautiously in those with a history of cardiovascular issues. Overall, cilostazol represents an important therapeutic option for managing symptoms of peripheral vascular disease.
Formula:C20H27N5O2
InChI:InChI=1S/C20H27N5O2/c26-20-12-9-15-14-17(10-11-18(15)21-20)27-13-5-4-8-19-22-23-24-25(19)16-6-2-1-3-7-16/h10-11,14,16H,1-9,12-13H2,(H,21,26)
InChI key:InChIKey=RRGUKTPIGVIEKM-UHFFFAOYSA-N
SMILES:C(CCCOC=1C=C2C(=CC1)NC(=O)CC2)C=3N(N=NN3)C4CCCCC4
Synonyms:- 2(1H)-Quinolinone, 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-
- Cilostazol
- Pletaal
- Cilostazole
- 6-[4-(1-Cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone
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