CAS 89371-44-8

Imidaprilat

Description:

Imidaprilat is an active metabolite of the angiotensin-converting enzyme (ACE) inhibitor imidapril, primarily used in the treatment of hypertension and heart failure. It functions by inhibiting the ACE enzyme, which plays a crucial role in the renin-angiotensin-aldosterone system, leading to vasodilation and reduced blood pressure. Imidaprilat is characterized by its ability to effectively lower blood pressure without causing significant reflex tachycardia. The substance is typically administered in its salt form, often as imidaprilat hydrochloride. It exhibits good solubility in water, which facilitates its absorption and bioavailability. The pharmacokinetics of imidaprilat include a relatively long half-life, allowing for once-daily dosing in clinical settings. Common side effects may include dizziness, fatigue, and potential electrolyte imbalances, particularly hyperkalemia. As with other ACE inhibitors, caution is advised in patients with renal impairment or those who are pregnant. Overall, imidaprilat is an important therapeutic agent in managing cardiovascular conditions.

Formula: C₁₈H₂₃N₃O₆

InChI: InChI=1S/C18H23N3O6/c1-11(15(22)21-14(17(25)26)10-20(2)18(21)27)19-13(16(23)24)9-8-12-6-4-3-5-7-12/h3-7,11,13-14,19H,8-10H2,1-2H3,(H,23,24)(H,25,26)/t11-,13-,14-/m0/s1

InChI key: InChIKey=VFAVNRVDTAPBNR-UBHSHLNASA-N

SMILES: C([C@@H](N[C@@H](CCC1=CC=CC=C1)C(O)=O)C)(=O)N2[C@H](C(O)=O)CN(C)C2=O

Synonyms:

• (4S)-3-[(2S)-2-[[(1S)-1-Carboxy-3-phenylpropyl]amino]-1-oxopropyl]-1-methyl-2-oxo-4-imidazolidinecarboxylic acid
• (4S)-3-[(2S)-N-[(1S)-1-Carboxy-3-phenylpropyl]alanyl]-1-methyl-2-oxo-4-imidazolidinecarboxylic acid
• (4S)-3-[(2S)-N-[(1S)-1-Carboxy-3-phenylpropyl]alanyl]-1-methyl-2-oxo-4-imidazolidinecarboxylicacid
• 4-Imidazolidinecarboxylic acid, 3-[(2S)-2-[[(1S)-1-carboxy-3-phenylpropyl]amino]-1-oxopropyl]-1-methyl-2-oxo-, (4S)-
• 4-Imidazolidinecarboxylic acid, 3-[2-[(1-carboxy-3-phenylpropyl)amino]-1-oxopropyl]-1-methyl-2-oxo-, [4S-[3[R*(R*)],4R*]]-
• 4-Imidazolidinecarboxylicacid, 3-[2-[(1-carboxy-3-phenylpropyl)amino]-1-oxopropyl]-1-methyl-2-oxo-,[4S-[3[R*(R*)],4R*]]-
• 6366A
• Imidaprilat
• Imidaprilate

Imidaprilat

CAS: 89371-44-8

Formula: C₁₈H₂₃N₃O₆

Color and Shape: Solid

Molecular weight: 377.3917

Ref: IN-DA003XKL

Imidaprilate

CAS: 89371-44-8

Imidaprilate, an active TA-6366 metabolite, is a potent ACE inhibitor with an IC50 of 2.6 nM, researched for hypertension.

Formula: C₁₈H₂₃N₃O₆

Purity: 98%

Color and Shape: Solid

Molecular weight: 377.39

Ref: TM-T11642

Imidaprilat-d5

CAS: 89371-44-8

Formula: C₁₈H₁₈D₅N₃O₆

Color and Shape: White To Off-White Solid

Molecular weight: 382.43

Ref: 4Z-I-144

Imidaprilat

CAS: 89371-44-8

Formula: C₁₈H₂₃N₃O₆

Color and Shape: White To Off-White Solid

Molecular weight: 377.40

Ref: 4Z-I-142

Imidaprilat

Controlled Product

CAS: 89371-44-8

Formula: C₁₈H₂₃N₃O₆

Color and Shape: Neat

Molecular weight: 377.39

Ref: TR-I275050