CAS 89396-94-1

Imidapril hydrochloride

Description:

Imidapril hydrochloride is an antihypertensive medication primarily used to treat high blood pressure and heart failure. It belongs to the class of drugs known as angiotensin-converting enzyme (ACE) inhibitors. The chemical structure of imidapril hydrochloride features a unique imidazole ring, which contributes to its pharmacological activity. As a prodrug, it is converted in the body to its active form, imidaprilat, which inhibits the ACE enzyme, leading to decreased production of angiotensin II, a potent vasoconstrictor. This results in vasodilation, reduced blood pressure, and decreased workload on the heart. Imidapril hydrochloride is typically administered orally and is well-absorbed, with a relatively long half-life allowing for once-daily dosing. Common side effects may include dizziness, cough, and elevated potassium levels. It is contraindicated in patients with a history of angioedema related to previous ACE inhibitor therapy and should be used cautiously in those with renal impairment. Overall, imidapril hydrochloride is an effective option in managing hypertension and related cardiovascular conditions.

Formula: C₂₀H₂₇N₃O₆

InChI: InChI=1S/C20H27N3O6.ClH/c1-4-29-19(27)15(11-10-14-8-6-5-7-9-14)21-13(2)17(24)23-16(18(25)26)12-22(3)20(23)28;/h5-9,13,15-16,21H,4,10-12H2,1-3H3,(H,25,26);1H/t13-,15-,16-;/m0./s1

InChI key: InChIKey=LSLQGMMMRMDXHN-GEUPQXMHSA-N

SMILES: C([C@@H](N[C@@H](CCC1=CC=CC=C1)C(OCC)=O)C)(=O)N2[C@H](C(O)=O)CN(C)C2=O.Cl

Synonyms:

• (-)-3-[N-[1(S)-(Ethoxycarbonyl)-3-phenylpropyl]-L-alanyl]-1-methyl-2-oxoimidazolidine-4(S)-carboxylic acid hydrochloride
• (S)-3-[(S)-2-((S)-1-Ethoxycarbonyl-3-Phenyl-Propylamino)-Propionyl]-1-Methyl-2-Oxo-Imidazolidine-4-Carboxylic Acid Hydrochloride
• 4-Imidazolidinecarboxylic acid, 3-[(2S)-2-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1-methyl-2-oxo-, hydrochloride (1:1), (4S)-
• 4-Imidazolidinecarboxylic acid, 3-[(2S)-2-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1-methyl-2-oxo-, monohydrochloride, (4S)-
• 4-Imidazolidinecarboxylic acid, 3-[2-[[1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1-methyl-2-oxo-, monohydrochloride, [4S-[3[R*(R*)],4R*]]-
• Imidapril HCl
• Imidapril hydrochloride
• Novaloc
• Novarok
• Sh-6366
• Ta-6366
• Tanapril
• Tanatril
• (-)-(4S)-3-[2(S)-[N-[1(S)-(Ethoxycarbonyl)-3-phenylpropyl]amino]propionyl]-1-methyl-2-oxoimidazolidine-4-carboxylic acid hydrochloride
• (S)-3-((S)-2-(((S)-1-Ethoxy-1-oxo-4-phenylbutan-2-yl)amino)propanoyl)-1-methyl-2-oxoimidazolidine-4-carboxylic acid hydrochloride
• 4-IMidazolidinecarboxylicacid,3-[(2S)-2-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]aMino]-1-oxopropyl]-1-Methyl-2-oxo-,hydrochloride (1:1), (4S)-
• (S)-3-[(S)-2-((S)-1-ETHOXYCARBONYL-3-PHENYL-PROPYLAMINO)-PROPIONYL]-1-METHYL-2-OXO-IMIDAZOLIDINE-4-CARBOXYLIC ACID USP/EP/BP
• 4-Imidazolidinecarboxylicacid,3-[(2S)-2-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1-methyl-2-oxo-,hydrochloride (1:1)
• (S)-3-[(S)-2-((S)-1-ETHOXYCARBONYL-3-PHENYL-PROPYLAMINO)-PROPIONYL]-1-METHYL-2-OXO-IMIDAZOLIDINE-4-CARBOXYLIC ACID
• ACE/TA-6366
• IMipadril HCl
• Imidaprilhydrochloride
• (-)-(4S)-3-[2(S)-[N-[1(S)-(Ethoxycarbonyl)-3-phenylpropyl]am...
• Imidapril Hydrochloride (cGMP)
• Imidapril hydrochloride [jan]
• ImidaprilHydrochloride&gt
• Imidapril HCl (TA-6366)
• Imidapril Hydrochloride (secondary standard)
• Imidapril monohydrochloride
• IMidapril HCL & its interMediates
• 3-[(2S)-2-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1-methyl-2-oxo-4-imidazolidinecarboxylic acid hydrochloride
• IMidapril Hydrochloride USP/EP/BP

(S)-3-[(S)-2-((S)-1-ETHOXYCARBONYL-3-PHENYL-PROPYLAMINO)-PROPIONYL]-1-METHYL-2-OXO-IMIDAZOLIDINE-4-CARBOXYLIC ACID

CAS: 89396-94-1

Formula: C₂₀H₂₈ClN₃O₆

Purity: 98%

Color and Shape: Solid

Molecular weight: 441.9058

Ref: IN-DA00GT8N

Imidapril HCl

CAS: 89396-94-1

Formula: C₂₀H₂₇N₃O₆·HCl

Color and Shape: White To Off-White Solid

Molecular weight: 405.45 36.46

Ref: 4Z-I-141

Imidapril Hydrochloride

CAS: 89371-37-9, 89396-94-1

Formula: C₂₀H₂₇N₃O₆·HCl

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 441.91

Ref: 3B-I0901

Imidapril hydrochloride

CAS: 89396-94-1

Formula: C₂₀H₂₇N₃O₆·HCl

Purity: 98.5 - 101.5 % (dried basis)

Color and Shape: White to off-white crystalline powder

Molecular weight: 441.91

Ref: 7W-GP3008

Imidapril hydrochloride

CAS: 89396-94-1

Imidapril hydrochloride (Tanapril) is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 2.6 nM, used for the treatment of hypertension.

Formula: C₂₀H₂₇N₃O₆·HCl

Purity: 99.31%

Color and Shape: Solid

Molecular weight: 441.91

Ref: TM-T6542

Imidapril Hydrochloride

CAS: 89396-94-1

Applications Angiotensin converting enzyme (ACE) inhibitor. Antihypertensive.
References Demolis, P., et al.: Fundam. Clin. Pharmacol., 8, 80 (1994), Vandenburg, M.J., et al.: Br. J. Clin. Pharmacol., 37, 265 (1994),

Formula: C₂₀H₂₇N₃O₆·ClH

Color and Shape: White Solid

Molecular weight: 441.91

Ref: TR-I275040

Imidapril hydrochloride

CAS: 89396-94-1

Angiotensin-converting enzyme inhibitor

Formula: C₂₀H₂₇N₃O₆•HCl

Purity: Min. 95%

Color and Shape: White To Off-White Solid

Molecular weight: 441.91 g/mol

Ref: 3D-FI24547

Imidapril Hydrochloride

CAS: 89396-94-1

Formula: C₂₀H₂₇N₃O₆

Molecular weight: 405.45

Ref: ST-EA-CP-I34003