CAS 893990-34-6

VU 0240551 

CAS: 893990-34-6

Formula: C₁₆H₁₄N₄OS₂

Purity: 99.9%

Color and Shape: Solid

Molecular weight: 342.4386

Ref: IN-DA003SD1

VU 0240551

CAS: 893990-34-6

VU 0240551

Purity: ≥98%

Molecular weight: 342.44g/mol

Ref: 54-BUP15006

N-(4-Methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]-acetamide

Controlled Product

CAS: 893990-34-6

Applications This molecule acts as an inhibitor of the K-Cl cotransporter KCC2, which is primarily responsible for maintaining intracellular Cl- concentrations including regulating an excess or lack of ions following periods of under or overstimulation, as well as general dendritic development.
References Delpire, E. et al.: Proc. Nat. Acad. Sci. USA., 106, 5383 (2009);

Formula: C₁₆H₁₄N₄OS₂

Color and Shape: Neat

Molecular weight: 342.44

Ref: TR-M330240

VU0240551

CAS: 893990-34-6

VU0240551 is a novel, potent, and selective allosteric modulator of the GABA receptor. It has been shown to have an excitatory effect in animal models of epilepsy and depression. VU0240551 has been shown to act as an allosteric modulator of α5-containing GABAA receptors, but not α1- or α2-containing GABAA receptors. This drug also potently increased chloride transport rates in mouse hippocampal neurons without affecting sodium or potassium transport rates. It has been proposed that this drug may be used for the treatment of seizures, depression, and chronic pain.
VU0240551 is currently being evaluated for its efficacy as a therapeutic agent for the treatment of epilepsy and depression by a Phase 2 clinical trial (NCT02696679).

Formula: C₁₆H₁₄N₄OS₂

Purity: Min. 95%

Molecular weight: 342.44 g/mol

Ref: 3D-TKB99034

VU 0240551

CAS: 893990-34-6

VU 0240551 is a selective antagonist of neuronal K-Cl cotransporter KCC2 inhibitor with an IC50 of 560 nM. VU 0240551 inhibits L-type calcium channels and hERG.

Formula: C₁₆H₁₄N₄OS₂

Purity: 99.9%

Color and Shape: Solid

Molecular weight: 342.44

Ref: TM-TQ0139