CAS 89419-40-9

Mosapramine

Description:

Mosapramine is a chemical compound classified as an atypical antipsychotic agent. It primarily acts as a serotonin and dopamine receptor antagonist, which contributes to its therapeutic effects in managing psychiatric disorders. The substance is known for its potential to alleviate symptoms of schizophrenia and other mood disorders. Mosapramine exhibits a complex pharmacological profile, influencing various neurotransmitter systems, including serotonin, dopamine, and norepinephrine pathways. Its chemical structure includes a piperazine ring, which is common among many psychotropic medications, enhancing its binding affinity to specific receptors in the brain. The compound is typically administered orally and has a moderate bioavailability. As with many psychotropic medications, mosapramine may present side effects, including sedation, weight gain, and metabolic changes, necessitating careful monitoring during treatment. Research into its efficacy and safety profile continues, contributing to the understanding of its role in psychiatric therapy. Overall, mosapramine represents a significant option in the pharmacological management of certain mental health conditions.

Formula: C₂₈H₃₅ClN₄O

InChI: InChI=1/C28H35ClN4O/c29-23-12-11-22-10-9-21-6-1-2-7-24(21)32(25(22)20-23)16-5-15-31-18-13-28(14-19-31)27(34)30-26-8-3-4-17-33(26)28/h1-2,6-7,11-12,20,26H,3-5,8-10,13-19H2,(H,30,34)

InChI key: InChIKey=PXUIZULXJVRBPC-UHFFFAOYSA-N

SMILES: O=C1C2(N3C(N1)CCCC3)CCN(CCCN4C=5C(CCC=6C4=CC=CC6)=CC=C(Cl)C5)CC2

Synonyms:

• (+-)-1'-(3-(3-Chloro-10,11-dihydro-5H-dibenz(b,f)azepin-5-yl)propyl)hexahydrospiro(imidazo(1,2-a)pyridine-3(2H),4'-piperidin)-2-one
• 1'-[3-(3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)propyl]hexahydro-2H-spiro[imidazo[1,2-a]pyridine-3,4'-piperidin]-2-one
• 5H-Dibenz[b,f]azepine, spiro[imidazo[1,2-a]pyridine-3(2H),4′-piperidin]-2-one deriv.
• Clospipramine
• Mosapramine [INN]
• Spiro[imidazo[1,2-a]pyridine-3(2H),4′-piperidin]-2-one, 1′-[3-(3-chloro-10,11-dihydro-5H-dibenz[b,f]azepin-5-yl)propyl]hexahydro-
• Unii-04Uzq7O9Sj
• Spiro[imidazo[1,2-a]pyridine-3(2H),4'-piperidin]-2-one, 1'-[3-(3-chloro-10,11-dihydro-5H-dibenz[b,f]azepin-5-yl)propyl]hexahydro- (9CI)
• (±)-1’-[3-(3-Chloro-10-11-dihydro-5H-dibenz[b，f]azepin-5-y1)propyl]hexahydrospim[irnidazo[1，2-α]pyridine-3(2H)，4'-piperidin]-2-one
• MOSAPRAMINE
• MOSAPRAMINE USP/EP/BP

Mosapramine

CAS: 89419-40-9

Formula: C₂₈H₃₅ClN₄O

Molecular weight: 479.0567

Ref: IN-DA0043PC

GSK-A1

CAS: 89419-40-9

GSK-A1

Purity: ≥98%

Molecular weight: 574.63g/mol

Ref: 54-BUP20674

Mosapramine

Controlled Product

CAS: 89419-40-9

Formula: C₂₈H₃₅ClN₄O

Color and Shape: Neat

Molecular weight: 479.057

Ref: TR-M873000

Mosapramine

CAS: 89419-40-9

Mosapramine is a drug that binds to the 5-HT1A receptor and has been shown to inhibit ion channels. In addition, it is an inhibitor of the reuptake of serotonin and noradrenaline in the brain. Mosapramine also inhibits the binding of ligands such as β-carbolines, morphine, and LSD to their receptors. Mosapramine is a potent antagonist at the 5-HT2A receptor with an IC50 value of 0.076 μM. Mosapramine is not active against other 5-HT receptors or any other neurotransmitter receptor types tested so far. It has been shown to inhibit cAMP production in human platelets and release in mouse platelets and rat cortical synaptosomes. This drug also has a high purity that allows it for use as a research tool for cell biology and pharmacology studies.

Formula: C₂₈H₃₅ClN₄O

Purity: Min. 95%

Molecular weight: 479.10 g/mol

Ref: 3D-PDA41940

Mosapramine

CAS: 89419-40-9

Mosapramine is a dopamine D2-receptor antagonist.

Formula: C₂₈H₃₅ClN₄O

Purity: 98%

Color and Shape: Solid

Molecular weight: 479.06

Ref: TM-T28086