CAS 894783-71-2

Nintedanib Carboxylic Acid

CAS: 894783-71-2

Formula: C₃₀H₃₁N₅O₄

Molecular weight: 525.61

Ref: ST-EA-CP-N24004

Nintedanib Acid ((Z)-3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylic acid)

CAS: 894783-71-2

Lactams, nesoi

Formula: C₃₀H₃₁N₅O₄

Color and Shape: Pale Yellow Solid

Molecular weight: 525.2376

Ref: 45-1A05640

(3Z)-2,3-Dihydro-3-[[[4-[methyl[2-(4-methyl-1-piperazinyl)acetyl]amino]phenyl]amino]phenylmethylene]-2-oxo-1H-indole-6-carboxylic acid

CAS: 894783-71-2

Formula: C₃₀H₃₁N₅O₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 525.5982

Ref: IN-DA00GU1U

Nintedanib Impurity 6 Ditrifluoroacetate

CAS: 894783-71-2

Formula: C₃₀H₃₁N₅O₄·2C₂HF₃O₂

Molecular weight: 525.61 2*114.02

Ref: 4Z-N-066094

BIBF 1202

CAS: 894783-71-2

BIBF 1202

Purity: ≥98%

Molecular weight: 525.6g/mol

Ref: 54-BUP10984

Nintedanib Impurity 6-13C-d3

CAS: 894783-71-2

Formula: C₂₉₁₃CH₂₈D₃N₅O₄

Color and Shape: Yellow Solid

Molecular weight: 529.62

Ref: 4Z-N-066054

Nintedanib Impurity 6

CAS: 894783-71-2

Formula: C₃₀H₃₁N₅O₄

Color and Shape: Yellow Solid

Molecular weight: 525.61

Ref: 4Z-N-066015

BIBF 1202

CAS: 894783-71-2

Molecular weight: 525.609

Ref: 10-F987629

(3Z)-2,3-Dihydro-3-[[[4-[methyl[2-(4-methyl-1-piperazinyl)acetyl]amino]phenyl]amino]phenylmethylene]-2-oxo-1H-indole-6-carboxylic Acid-D3

Controlled Product

CAS: 894783-71-2

Applications (3Z)-2,3-Dihydro-3-[[[4-[methyl[2-(4-methyl-1-piperazinyl)acetyl]amino]phenyl]amino]phenylmethylene]-2-oxo-1H-indole-6-carboxylic Acid-D3 is an intermediate used in the synthesis of Nintedanib Demethyl-O-glucuronic Acid-d3 (N478297), which is an isotopic analog of Nintedanib Demethyl-O-glucuronic Acid (N478295), a metabolite of the drug Nintedanib (N478290).
References Sun, L., et al.: J. Med. Chem., 41, 2588 (1998); Xie, H., et al.: J. Med. Chem., 50, 4898 (2007); Hilberg, F., et al.: Cancer Res., 68, 4774 (2008); Roth, G., et al.: J. Med. Chem., 58, 1053 (2015)

Formula: C₃₀D₃H₂₈N₅O₄

Color and Shape: Neat

Molecular weight: 528.617

Ref: TR-D454387

Nintedanib Carboxylic Acid

CAS: 894783-71-2

Formula: C₃₀H₃₁N₅O₄

Color and Shape: Yellow Solid

Molecular weight: 525.60

Ref: TR-N478285

BIBF 1202

CAS: 894783-71-2

BIBF 1202 is a VEGFR2 kinase inhibitor (IC50 = 62 nM).

Formula: C₃₀H₃₁N₅O₄

Purity: 98.04%

Color and Shape: Solid

Molecular weight: 525.6

Ref: TM-TQ0321

BIBF 1202

CAS: 894783-71-2

BIBF 1202 is a potent inhibitor of phospholipase A2, prostaglandin synthase and cyclooxygenase-2. It inhibits the production of arachidonic acid from membrane phospholipids and is used in cancer research. BIBF 1202 has been shown to have anti-tumour activity in a number of animal models, including human liver cancer cells. This molecule has also been shown to inhibit the activation of nuclear factor kappa B (NF-κB), which is involved in carcinogenesis.

Formula: C₃₀H₃₁N₅O₄

Purity: Min. 95%

Molecular weight: 525.6 g/mol

Ref: 3D-UKB78371