CAS 89778-26-7

Toremifene

Description:

Toremifene is a non-steroidal selective estrogen receptor modulator (SERM) primarily used in the treatment of breast cancer, particularly in postmenopausal women. It functions by binding to estrogen receptors, thereby inhibiting the effects of estrogen on breast tissue, which can help slow or stop the growth of estrogen-dependent tumors. Toremifene is characterized by its ability to exhibit both estrogenic and anti-estrogenic properties, depending on the target tissue. It is typically administered orally and is known for its relatively favorable side effect profile compared to other hormonal therapies. The chemical structure of toremifene includes a triphenylethylene backbone, which is common among SERMs, contributing to its biological activity. Additionally, it has a moderate half-life, allowing for once-daily dosing in clinical settings. As with any medication, monitoring for potential side effects, including hot flashes, nausea, and risk of thromboembolic events, is essential during treatment. Overall, toremifene represents an important therapeutic option in the management of hormone receptor-positive breast cancer.

Formula: C₂₆H₂₈ClNO

InChI: InChI=1S/C26H28ClNO/c1-28(2)19-20-29-24-15-13-23(14-16-24)26(22-11-7-4-8-12-22)25(17-18-27)21-9-5-3-6-10-21/h3-16H,17-20H2,1-2H3/b26-25-

InChI key: InChIKey=XFCLJVABOIYOMF-QPLCGJKRSA-N

SMILES: C(=C(/CCCl)\C1=CC=CC=C1)(\C2=CC=C(OCCN(C)C)C=C2)/C3=CC=CC=C3

Synonyms:

• 2-Hydroxypropan-1,2,3-tricarbons?ure--2-{4-[(1Z)-4-chlor-1,2-diphenylbut-1-en-1-yl]phenoxy}-N,N-dimethylethanamin(1:1)
• 2-[4-[(1Z)-4-Chloro-1,2-diphenyl-1-buten-1-yl]phenoxy]-N,N-dimethylethanamine
• 2-{4-[(1Z)-4-Chloro-1,2-diphenyl-1-buten-1-yl]phenoxy}-N,N-dimethylethanamine 2-hydroxy-1,2,3-propanetricarboxylate (1:1)
• 2-{4-[(1Z)-4-Chloro-1,2-diphenyl-1-buten-1-yl]phenoxy}-N,N-dimethylethanamine 2-hydroxy-1,2,3-propanetricarboxylate (salt)
• 2-{4-[(1Z)-4-Chloro-1,2-diphenylbut-1-en-1-yl]phenoxy}-N,N-dimethylethanamine 2-hydroxypropane-1,2,3-tricarboxylate (1:1)
• 2-{4-[(1Z)-4-chloro-1,2-diphenylbut-1-en-1-yl]phenoxy}-N,N-dimethylethanamine 2-hydroxypropane-1,2,3-tricarboxylate (salt)
• Acapodene
• Chlortamoxifen
• Ethanamine, 2-[4-(4-chloro-1,2-diphenyl-1-butenyl)phenoxy]-N,N-dimethyl-, (Z)-
• Ethanamine, 2-[4-[(1Z)-4-chloro-1,2-diphenyl-1-buten-1-yl]phenoxy]-N,N-dimethyl-
• Ethanamine, 2-[4-[(1Z)-4-chloro-1,2-diphenyl-1-butenyl]phenoxy]-N,N-dimethyl-
• Farestone
• GTx 006
• Z-Toremifene
• acide 2-hydroxypropane-1,2,3-tricarboxylique - 2-{4-[(1Z)-4-chloro-1,2-diphénylbut-1-én-1-yl]phénoxy}-N,N-diméthyléthanamine (1:1)
• ethanamine, 2-[4-[(1Z)-4-chloro-1,2-diphenyl-1-buten-1-yl]phenoxy]-N,N-dimethyl-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1) (salt)
• ethanamine, 2-[4-[(1Z)-4-chloro-1,2-diphenyl-1-butenyl]phenoxy]-N,N-dimethyl-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1) (salt)

Toremifene Citrate

CAS: 89778-26-7, 89778-27-8

Formula: C₂₆H₂₈ClNO·C₆H₈O₇

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 598.09

Ref: 3B-T2832

Toremifene

CAS: 89778-26-7

Toremifene (GTx 006) is a selective estrogen-receptor modulator (SERM).

Formula: C₂₆H₂₈ClNO

Purity: 99.77% - >99.99%

Color and Shape: White-To-Off-White Solid

Molecular weight: 405.96

Ref: TM-T0139

Toremifene-d6

CAS: 89778-26-7

Formula: C₂₆H₂₂D₆ClNO

Color and Shape: White To Off-White Solid

Molecular weight: 412.00

Ref: 4Z-T-412

Toremifene

Controlled Product

CAS: 89778-26-7

Applications Toremifene is an analog of chlorinated tamoxifen and an antiproliferative agent.
References Verma, V., et al.: Toxicol. Appl. Pharmacol., 280, 323 (2014); Hong, A., et al.: Chemotherapy 48, 238 (2002)

Formula: C₂₆H₂₈ClNO

Color and Shape: White To Off-White

Molecular weight: 405.96

Ref: TR-T547513

Toremifene

CAS: 89778-26-7

Formula: C₂₆H₂₈ClNO

Purity: 98%

Color and Shape: Solid

Molecular weight: 405.9596

Ref: IN-DA00400M