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CAS 89992-70-1

:

2-Cyanoethyl N,N-diisopropylchlorophosphoramidite

Description:
2-Cyanoethyl N,N-diisopropylchlorophosphoramidite is a chemical compound commonly used in the field of organic synthesis, particularly in the preparation of oligonucleotides. It features a phosphoramidite structure, which is characterized by a phosphorus atom bonded to an amine and an alkoxy group, along with a cyanoethyl group that enhances its reactivity. This compound is typically a colorless to pale yellow liquid and is sensitive to moisture, requiring careful handling and storage under an inert atmosphere to prevent hydrolysis. Its chlorophosphoramidite functionality allows for the efficient coupling with nucleosides, making it a valuable reagent in the synthesis of DNA and RNA sequences. Additionally, the presence of the diisopropyl groups contributes to the steric hindrance, which can influence the reactivity and selectivity during chemical reactions. Safety precautions are essential when working with this compound, as it may pose health risks if inhaled or ingested, and appropriate personal protective equipment should be used.
Formula:C9H18ClN2OP
InChI:InChI=1S/C9H18ClN2OP/c1-8(2)12(9(3)4)14(10)13-7-5-6-11/h8-9H,5,7H2,1-4H3
InChI key:InChIKey=QWTBDIBOOIAZEF-UHFFFAOYSA-N
SMILES:N(P(OCCC#N)Cl)(C(C)C)C(C)C
Synonyms:
  • (2-Cyanoethoxy)(Diisopropylamino)chlorophosphine
  • (2-Cyanoethoxy)(N,N-diisopropylamino)chlorophosphine
  • (2-Cyanoethoxy)(diisopropylamino)chlorophosphane
  • (2-O-Cyanoethyl)(N,N-diisopropylamino)chlorophosphine
  • 2-Cyanoethyl N,N-diisopropylchloro phosphoroamidite
  • 2-Cyanoethyl N,N-diisopropylchlorophosphoramidite
  • 2-Cyanoethyl N,N-diisopropylchlorophosphoroamidite
  • 2-Cyanoethyl N,N-diisopropylphosphoramidochloridite
  • 2-Cyanoethyl diisopropylchlorophosphoramidite
  • 2-Cyanoethyl diisopropylphosphoramidochloridite
  • See more synonyms
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Found 2 products.
  • 2-Cyanoethyl diisopropylchlorophosphoramidite, 95%
    Alfa Aesar By Thermo Fisher Scientific
    + Info

    2-Cyanoethyl diisopropylchlorophosphoramidite, 95%

    CAS:
    <p>2-Cyanoethyl diisopropylchlorophosphoramidite is a useful intermediate in organic synthesis. It acts as a protecting reagent in DNA synthesis. It is involved in the selective monophosphorylation of carbohydrates and nucleosides. It plays an essential role in the conversion of protected ribonucleosides to phosphoramidites. It is also utilized as phosphitylating reagent for 3'-hydroxyl groups in the synthesis of oligodeoxyribonucleotides. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.</p>
    Formula:C9H18ClN2OP
    Purity:95%
    Color and Shape:Liquid, Clear to turbid or hazy colorless to yellow
    Molecular weight:236.68

    Ref: 02-L18575

    1g
    Discontinued
    5g
    Discontinued
    Discontinued product
  • Cyanoethyl N,N-Diisopropyl Phosphoamidochloridite
    TRC
    + Info

    Cyanoethyl N,N-Diisopropyl Phosphoamidochloridite

    CAS:
    Formula:C9H18ClN2OP
    Color and Shape:Colourless to Yellow Oil
    Molecular weight:236.68

    Ref: TR-C980000

    5g
    Discontinued
    Discontinued product