CAS 90-34-6

Primaquine

Description:

Primaquine is an antimalarial medication primarily used to treat and prevent malaria, particularly the relapse of Plasmodium vivax and Plasmodium ovale infections. It is classified as an 8-aminoquinoline compound and is known for its ability to target the liver stages of the malaria parasite. The chemical formula of primaquine is C15H18N3O, and it has a molecular weight of approximately 245.33 g/mol. This compound is typically administered in its phosphate salt form, which enhances its solubility. Primaquine is characterized by its relatively low solubility in water but is soluble in organic solvents. Its mechanism of action involves the generation of reactive oxygen species that damage the parasite's cellular components. While effective, primaquine can cause hemolytic anemia in individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency, necessitating screening before use. Additionally, it has a half-life of several hours, requiring multiple doses for effective treatment. Overall, primaquine plays a crucial role in malaria eradication efforts, particularly in preventing relapses.

Formula: C₁₅H₂₁N₃O

InChI: InChI=1S/C15H21N3O/c1-11(5-3-7-16)18-14-10-13(19-2)9-12-6-4-8-17-15(12)14/h4,6,8-11,18H,3,5,7,16H2,1-2H3

InChI key: InChIKey=INDBQLZJXZLFIT-UHFFFAOYSA-N

SMILES: N(C(CCCN)C)C=1C2=C(C=C(OC)C1)C=CC=N2

Synonyms:

• 1,4-Pentanediamine, N4-(6-methoxy-8-quinolinyl)-
• 1,4-Pentanediamine, N⁴-(6-methoxy-8-quinolinyl)-
• 4-Amino-1-Methylbutyl(6-Methoxy-8-Quinolyl)Amine
• 6-Methoxy-8-[4-amino-1-methylbutylamino]quinoline
• 8-(4-Amino-1-methylbutylamino)-6-methoxyquinoline
• 8-[4'-Amino-1'-methylbutyl) amino]-6-methoxyquinoline
• Leoprime
• Malirid
• Maliride
• N⁴-(6-Methoxy-8-quinolinyl)-1,4-pentanediamine
• Neo-Quipenyl
• Nsc 27296
• Pimaquin
• Primachin
• Primacip
• Primalex
• Primaquin
• Primaquina
• Quinoline, 8-[(4-amino-1-methylbutyl)amino]-6-methoxy-
• Sn 13272
• Wr 2975
• dl-Primaquine

N-(5-aminopentan-2-yl)-6-methoxyquinolin-8-amine

CAS: 90-34-6

Formula: C₁₅H₂₁N₃O

Purity: 95%

Color and Shape: Solid

Molecular weight: 259.3467

Ref: IN-DA00IFY1

Primaquine phosphate

CAS: 90-34-6

Formula: C₁₅H₂₇N₃O₉P₂

Purity: ≥ 95.0%

Color and Shape: Orange to red or brown powder

Molecular weight: 455.34

Ref: 7W-GP6745

8-(4-Amino-1-methylbutylamino)-6-methoxyquinoline

CAS: 90-34-6

8-(4-Amino-1-methylbutylamino)-6-methoxyquinoline

Purity: 95%

Molecular weight: 259.35g/mol

Ref: 54-OR1074705

Primaquine

Controlled Product

CAS: 90-34-6

Applications Primaquine is an intermediate in the synthesis of Primaquine-d3 Diphosphate (P733502). Primaquine-d3 Diphosphate is an isotope labelled Primaquine (P733500), which is an antimalarial.
References Marrs, T., et al.: Toxicol Lett., 36, 281 (1987); Karbwang, J., et al.: Clin. Pharmacokinetic., 27, 104 (1994); Noedl, H., et al.: Antimicrob. Agents Chemother., 45, 2106 (2010)

Formula: C₁₅H₂₁N₃O

Color and Shape: Neat

Molecular weight: 259.35

Ref: TR-P733505

Primaquine

CAS: 90-34-6

Primaquine is an antimalarial agent with action on Plasmodium hypnozoites in the liver and is used for preventing relapses of malaria caused by Plasmodium vivax and Plasmodium ovale.

Formula: C₁₅H₂₁N₃O

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 259.35 g/mol

Ref: 3D-FA42456

Primaquine

CAS: 90-34-6

Primaquine is an antimalarial compound and a gametocytocide, clearing liver schizonts and dormant forms of Plasmodium vivax.

Formula: C₁₅H₂₁N₃O

Purity: 98.62%

Color and Shape: Solid

Molecular weight: 259.35

Ref: TM-T60411

8-(4-Amino-1-methylbutylamino)-6-methoxyquinoline

CAS: 90-34-6

Formula: C₁₅H₂₁N₃O

Purity: 95%

Color and Shape: Solid

Molecular weight: 259.353

Ref: 10-F079201