CAS 90-69-7

(-)-Lobeline

Description:

(-)-Lobeline is a naturally occurring alkaloid primarily derived from the plant Lobelia inflata, commonly known as Indian tobacco. It is characterized by its complex bicyclic structure, which includes a piperidine ring. This compound exhibits a range of pharmacological properties, including stimulant effects on the central nervous system and potential applications in smoking cessation therapies due to its ability to modulate nicotinic acetylcholine receptors. (-)-Lobeline has been studied for its effects on neurotransmitter release and may influence dopamine pathways, making it of interest in addiction research. The substance is typically found as a white to off-white crystalline powder and is soluble in water and alcohol. Its stereochemistry is significant, as the (-) enantiomer is the biologically active form. Safety and toxicity profiles indicate that while it has therapeutic potential, caution is advised due to possible side effects and interactions with other medications. Overall, (-)-Lobeline represents a fascinating compound with both historical significance and contemporary relevance in pharmacology.

Formula: C₂₂H₂₇NO₂

InChI: InChI=1/C22H27NO2/c1-23-19(15-21(24)17-9-4-2-5-10-17)13-8-14-20(23)16-22(25)18-11-6-3-7-12-18/h2-7,9-12,19-21,24H,8,13-16H2,1H3

InChI key: InChIKey=MXYUKLILVYORSK-HBMCJLEFSA-N

SMILES: C([C@H](O)C1=CC=CC=C1)[C@H]2N(C)[C@@H](CC(=O)C3=CC=CC=C3)CCC2

Synonyms:

• (-)-α-Lobeline
• 2-[(2R,6S)-6-[(2S)-2-Hydroxy-2-phenylethyl]-1-methyl-2-piperidinyl]-1-phenylethanone
• 2-[6-(2-Hydroxy-2-Phenylethyl)-1-Methylpiperidin-2-Yl]-1-Phenylethanone
• 2-[6-(β-Hydroxyphenethyl)-1-methyl-2-piperidyl]acetophenone
• 8,10-Diphenyllobelionol
• <span class="text-smallcaps">L</span>-Lobeline
• Ethanone, 2-[(2R,6S)-6-[(2S)-2-hydroxy-2-phenylethyl]-1-methyl-2-piperidinyl]-1-phenyl-
• Ethanone, 2-[6-(2-hydroxy-2-phenylethyl)-1-methyl-2-piperidinyl]-1-phenyl-, [2R-[2α,6α(S*)]]-
• Inflatine
• Lobelidine
• Lobelin
• Lobeline
• Lobnico
• Nih 11034
• l-Lobeline
• LOBELIDINE95%,98%
• LOBELINE HCl, a-(P)
• L-lobeline free base
• Lobeline USP/EP/BP
• (-)-α-[(2R,6S)-6-[(S)-β-hydroxyphenethyl]-1-methyl-2-piperidinyl]acetophenone
• 2-(6-[2-Hydroxy-2-phenylethyl]-1-methyl-2-piperidinyl)-1-phenylethanone
• C07475

Lobelin

CAS: 90-69-7

Capsaicin inhalation and Lobelin, Alinamin IV injections suggest peripheral c-fiber receptors trigger coughing.

Formula: C₂₂H₂₇NO₂

Purity: 98%

Color and Shape: Rosettes Of Slender Needles From Alc Solid

Molecular weight: 337.46

Ref: TM-TL0018

L-Lobeline

CAS: 90-69-7

L-Lobeline is a natural alkaloid, which is derived from the plant Lobelia inflata. It functions primarily as a nicotinic receptor agonist, but also exhibits antagonistic activity depending on the subtype of the receptor. This dual action enables it to modulate various neurotransmitter systems. L-Lobeline is known to influence catecholamine release and inhibit dopamine uptake, thus affecting synaptic transmission.

Formula: C₂₂H₂₇NO₂

Molecular weight: 337.46 g/mol

Ref: 3D-OL174235