CAS 9000-94-6: Antithrombin

Description:Antithrombin, with the CAS number 9000-94-6, is a glycoprotein that plays a crucial role in the regulation of blood coagulation. It is primarily produced in the liver and functions as a serine protease inhibitor, specifically targeting thrombin and factor Xa, which are key enzymes in the coagulation cascade. Antithrombin's activity is enhanced by heparin, a naturally occurring anticoagulant, which increases its ability to inhibit clot formation. The protein is composed of multiple domains, including a reactive center loop that is essential for its inhibitory function. Deficiencies or dysfunctions in antithrombin can lead to an increased risk of thromboembolic disorders, such as deep vein thrombosis and pulmonary embolism. Clinically, antithrombin is utilized in therapeutic settings, particularly in patients with congenital antithrombin deficiency or those undergoing certain surgical procedures. Its molecular weight varies due to glycosylation, and it is typically measured in units of activity rather than concentration. Overall, antithrombin is a vital component of the hemostatic system, maintaining the balance between coagulation and anticoagulation.

Formula:Unspecified