Arginase is an enzyme that plays a crucial role in the urea cycle, catalyzing the hydrolysis of arginine to ornithine and urea. It is primarily found in the liver, where it facilitates the removal of excess nitrogen from the body. Arginase exists in two isoforms, arginase I and arginase II, which differ in their tissue distribution and regulatory mechanisms. The enzyme is a manganese-dependent metalloenzyme, requiring manganese ions for its activity. Arginase is involved in various physiological processes, including the regulation of nitric oxide synthesis and the modulation of immune responses. Its activity can be influenced by factors such as pH, temperature, and the presence of specific inhibitors or activators. Dysregulation of arginase activity has been implicated in several pathological conditions, including cardiovascular diseases and certain cancers. As a therapeutic target, arginase has garnered interest in drug development, particularly in the context of cancer immunotherapy and metabolic disorders. The CAS number 9000-96-8 identifies arginase in chemical databases, facilitating research and regulatory processes.

Arginase

9000-96-8: Arginase is an enzyme that plays a crucial role in the urea cycle, catalyzing the hydrolysis of arginine to ornithine and urea. It is primarily found in the liver, where it facilitates the removal of excess nitrogen from the body. Arginase exists in two isoforms, arginase I and arginase II, which differ in their tissue distribution and regulatory mechanisms. The enzyme is a manganese-dependent metalloenzyme, requiring manganese ions for its activity. Arginase is involved in various physiological processes, including the regulation of nitric oxide synthesis and the modulation of immune responses. Its activity can be influenced by factors such as pH, temperature, and the presence of specific inhibitors or activators. Dysregulation of arginase activity has been implicated in several pathological conditions, including cardiovascular diseases and certain cancers. As a therapeutic target, arginase has garnered interest in drug development, particularly in the context of cancer immunotherapy and metabolic disorders. The CAS number 9000-96-8 identifies arginase in chemical databases, facilitating research and regulatory processes.

<p>Arginase (L-Arginine amidinase) is a key hydrolytic enzyme in the urea cycle, which hydrolyzes L-arginine into urea and L-ornithine.</p>

CAS 9000-96-8

Arginase

Arginase

Ref: TM-T76208